Actively Recruiting
A Prospective Cluster-Randomized, Controlled Crossover Trial to Validate an Electronic "Resistance Calculator"
Led by Dror MarChaim, MD · Updated on 2024-07-31
1500
Participants Needed
2
Research Sites
78 weeks
Total Duration
On this page
Sponsors
D
Dror MarChaim, MD
Lead Sponsor
H
Hadassah Medical Organization
Collaborating Sponsor
AI-Summary
What this Trial Is About
Primary objective: \- Our aim is to validate the "Shamir Resistance Calculator" in a prospective crossover trial, in order to shorten the time to initiation of appropriate antimicrobials among hospitalized septic patients. Secondary objectives: \- To evaluate the impact of using the "Shamir Resistance Calculator" with regards to: * new acquisitions of multi-drug resistant organisms (MDRO) * the empiric usage of broad-spectrum agents (e.g., carbapenems, vancomycin) * acute Clostridiodes difficile infections * In-hospital mortality.
CONDITIONS
Official Title
A Prospective Cluster-Randomized, Controlled Crossover Trial to Validate an Electronic "Resistance Calculator"
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients aged over 18 years
- Patients hospitalized at Shamir Medical Center or Hadassah Medical Organization during the study period
- Patients who started empiric antibiotic treatment due to acute sepsis
- Sepsis defined by established clinical criteria
- Patients admitted to the emergency room but not discharged home or transferred to another facility without hospitalization
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Shamir Medical Center (Assaf Harofeh)
Be’er Ya‘aqov, Israel, 70300
Actively Recruiting
2
Hadassah Medical Organization
Jerusalem, Israel, 91120
Actively Recruiting
Research Team
D
Dror Marchaim, M.D
CONTACT
R
Ron Finkenberg
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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