Actively Recruiting
A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP
Led by Shanghai 6th People's Hospital · Updated on 2025-04-20
100
Participants Needed
1
Research Sites
112 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Through a prospective cohort study, we aim to dynamically evaluate the long-term benefits and risks associated with surgical interventions for hereditary spastic paraparesis (HSP) accompanied by foot deformities. Our goal is to systematically summarize clinical experiences to guide practice and ultimately optimize patient outcomes. The core research objectives include elucidating: 1. the long-term efficacy of foot deformity correction procedures; 2. the optimal timing for surgical intervention; 3. the establishment of objective evaluation criteria to guide therapeutic decision-making.
CONDITIONS
Official Title
A Prospective Cohort Study of Surgical Treatment for Foot Deformities in HSP
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 10 and 45 years old
- Confirmed clinical and molecular diagnosis of hereditary spastic paraparesis (HSP) with isolated Achilles tendon contracture or equinovarus cavus deformity
- Imaging evidence (X-ray or CT) confirming the specific foot deformity
- Signed informed consent agreeing to participate in the study
- Poor response to standard non-surgical treatments with worsening gait and foot deformities
- Functional impairments like walking pain, frequent falls, and reduced quality of life due to the foot deformity
- Ability to walk barefoot for at least 10 meters independently or with assistive devices
You will not qualify if you...
- Previous foot or ankle orthopedic surgery
- Severe cognitive problems or inability to follow post-surgery care and assessments
- Foot deformities caused by other conditions such as diabetes, infections, or inflammatory arthritis
- Serious vascular disease or unstable medical issues like cancer, blood disorders, or organ failure
- Other neurodegenerative or neuromuscular diseases not related to HSP
- Poor compliance with study rules or other reasons preventing participation in the trial
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Shanghai, Shanghai Municipality, China, 213000
Actively Recruiting
Research Team
L
Li Cao, phD
CONTACT
W
Wo tu Tian, phD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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