Cancer statistics, 2006.
Ahmedin Jemal, Rebecca Siegel, Elizabeth Ward...
https://pubmed.ncbi.nlm.nih.gov/16514137Actively Recruiting
Age: 4Years +
All Genders
ID01005654
Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms
Led by National Cancer Institute (NCI) · Updated on 2026-06-08
2415
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Endocrine tumors, including those of the thyroid, parathyroid, adrenal gland, pancreas, and other neuroendocrine tissues, are increasing rapidly in incidence and can be challenging to classify as benign or malignant. Researchers aim to study the molecular changes involved in the development and growth of these endocrine cancers. This observational study focuses on collecting samples from patients undergoing surgery or biopsy for these tumors to better understand their genetic, epigenetic, metabolomic, and proteomic profiles. Participants scheduled for surgery or biopsy of endocrine tumors will provide blood and urine samples before the procedure. During surgery, tumor or precancerous tissue and nearby normal tissue will be collected for research purposes. After surgery, participants will receive standard care and follow-up visits, including a postoperative check approximately six weeks later and yearly follow-ups either in person or by phone. Throughout the study, researchers will analyze the collected tissues and samples to develop profiles that distinguish benign from malignant tumors and study gene expression and molecular changes. Participants will be monitored for clinical outcomes and receive routine care as determined by their doctors. The total follow-up duration can extend up to 10 years to support long-term research goals.
CONDITIONS
Brief Title
Prospective Comprehensive Molecular Analysis of Endocrine Neoplasms
Who Can Participate
Age: 4Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Participants with endocrine tumors or pre-malignant conditions based on radiographic, biochemical, or biopsy evidence involving thyroid, parathyroid, adrenal, pancreas, or related neuroendocrine tissues
- Participants referred for surgical evaluation of endocrine disorders
- Participants with an ECOG performance score of 0 to 2
- Participants with physical exam results within acceptable limits for surgery or biopsy
- Participants planning to undergo surgery or biopsy as part of their treatment
- Participants aged 4 years or older
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
Surgery and Immediate Post-operative Care
Duration - Day of surgery or biopsy
Participants undergo surgery or biopsy to obtain tissue samples of endocrine neoplasms or pre-malignant conditions as part of routine care. Blood samples are also collected during the procedure.
1 visit (in-person)
Long-term Monitoring
Duration - Up to 10 years
Participants are followed for up to 10 years to monitor clinical outcomes and correlate with molecular analyses of the tissue samples.
Trial Site Locations
Total: 1 location
1
National Institutes of Health Clinical Center
Bethesda, Maryland, United States, 20892
Actively Recruiting
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Research Team
K
Kristine J Villaruel
N
Naris Nilubol, M.D.
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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