Prospective Study of Radiotherapy Using the RefleXion Medical System to Treat Various Cancers Including Assessment of Quality of Life and Treatment Effects

What this Trial Is About

Researchers are evaluating the use of the RefleXion Medical Radiotherapy System RMRS to deliver three types of radiation treatments intensity-modulated radiotherapy IMRT, stereotactic body radiotherapy SBRT, and biology-guided radiotherapy BgRT for patients with local, loco-regionally advanced, or metastatic cancers. This prospective registry study aims to assess clinical outcomes, quality of life, and the severity of side effects from these treatments, while also analyzing patient costs and the quality of radiotherapy planning. The study involves multiple cancer types including central nervous system, head and neck, thoracic, gastrointestinal, gynecologic, genitourinary, lymphoma, and others. Participants will receive standard radiotherapy treatment using RMRS with the type of therapy IMRT, SBRT, or BgRT determined by the radiation oncology team. The study plans to enroll about 750 patients divided evenly among the three treatment methods. Treatment doses, schedules, and any additional systemic therapies will follow standard care practices. Patients will be assessed routinely during treatment and followed for up to two years to monitor side effects, quality of life, and disease status. During the study, participants will complete quality of life surveys and undergo regular assessments including toxicity evaluations, laboratory tests, physical exams, and imaging as part of their standard care. Data on health-related quality of life will be collected at multiple time points up to 24 months after treatment. Researchers will also track costs and charges associated with the treatments. This long-term follow-up will help understand both the clinical and economic impact of radiotherapy using the RMRS.

Prospective Data Registry and Quality of Life Assessment of Patients Undergoing Radiotherapy With the RefleXion Medical Radiotherapy System