Actively Recruiting
Prospective Evaluation of Asians With CRT for Heart Failure
Led by National University Heart Centre, Singapore · Updated on 2021-03-09
500
Participants Needed
1
Research Sites
1039 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Aim:To determine the baseline characteristics of heart failure patients in Singapore undergoing cardiac resynchronization therapy (CRT); the long term outcome and predictors of response to CRT. Methodology:Among patients undergoing CRT for severe heart failure according to indications stipulated in international Cardiology guidelines, baseline demographic data is collected. Age, gender, NYHA functional class, co-morbidities, QRS width on ECG, presence of left bundle branch block pattern on ECG, presence of atrial fibrillation, left ventricular ejection fraction (LVEF) on echocardiogram, ventricular dimensions, 6 min walk test distance are collected. In addition, during the CRT implant procedure, blood is drawn from the vascular access and analysed for NT-pro BNP levels and other biomarkers of heart failure. The echocardiographic and ECG parameters and blood biomarkers are reanalysed at 6 months and 12 months following CRT implant. Response to CRT is defined as a reduction in the iLVESV (left ventricular end-systolic volume index to body surface area) of \>/= 15% and/or an increase in the LVEF of \>/= 10%.
CONDITIONS
Official Title
Prospective Evaluation of Asians With CRT for Heart Failure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Broad QRS greater than 120 milliseconds
- Ejection fraction less than 40%
- Symptomatic heart failure
- Not on optimal medical therapy
You will not qualify if you...
- Pregnant
- Younger than 18 years of age
- Infection
- Unable to provide informed consent
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
National University Hospital
Singapore, Singapore
Actively Recruiting
Research Team
P
Pipin Kojodjojo, MD PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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