Actively Recruiting
Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies
Led by M.D. Anderson Cancer Center · Updated on 2025-10-14
2345
Participants Needed
1
Research Sites
695 weeks
Total Duration
On this page
Sponsors
M
M.D. Anderson Cancer Center
Lead Sponsor
N
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The Coordinating and Data Management Center (CDMC) at MD Anderson Cancer will be responsible for the coordination and data management for the Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies (PROCCEED) Study, which is part of the NIH U01 funded Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC). No patient enrollment will occur at MDACC. All patient recruitment will occur at external sites that are a part of the CPDPC. The data management systems, auditing, and monitoring effort are supported by the MD Anderson Cancer Center Clinical Research Support Center (CRSC). PROCEED is the first study in the USA that is carefully following participants to better understand factors that may be responsible for causing pancreatitis and how it progresses. The study is being conducted at the following 9 major clinical centers across the US: * Baylor College of Medicine * Cedars-Sinai Medical Center * University of Florida * Indiana University * Mayo Clinic * University of Minnesota * Ohio State University * Stanford University * University of Pittsburgh The study is enrolling participants who are at different stages of chronic pancreatitis, including those with no known pancreas disease (controls), and those with abdominal pain, one or more attacks of pancreatitis, or chronic pancreatitis. After enrollment, participants with abdominal pain and pancreatitis are asked to follow-up every year to learn about their symptoms and any changes in the disease. PROCEED investigators plan to use the detailed information they collect to better understand the disease and identify new treatments. "More details and updated information about this study can be found at the study's public website: https://www.cpdpc-research-consortium.org/research- study-cpdpc-16-02-proceed".
CONDITIONS
Official Title
Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with chronic pancreatitis
You will not qualify if you...
- History of autoimmune or traumatic pancreatitis, or sentinel attack of acute necrotizing pancreatitis
- Presence of primary pancreatic tumors such as pancreatic ductal adenocarcinoma, cystic neoplasm larger than 1 cm or involving the main duct, neuroendocrine or other uncommon tumors
- Pancreatic metastasis from other cancers
- History of solid organ transplant or HIV/AIDS
- Known isolated pancreatic exocrine insufficiency without other inclusion criteria
- Medical or psychiatric illnesses or substance abuse that would affect participation or tolerance of study procedures
- Abnormal kidney function with creatinine clearance (GFR) less than 30 or renal failure for certain subgroups
- Refusal to agree to longitudinal follow-up
- Known pregnancy or positive pregnancy test within 2 days before research procedures for participants of childbearing potential
- Currently incarcerated
- Inability to undergo MRI/MRCP at baseline due to metal implants or other contraindications in specific subgroups
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Texas MD Anderson Cancer Center
Houston, Texas, United States, 77339
Actively Recruiting
Research Team
L
Li Liang, PHD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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