Prospective Study on the Use of Peroral Endoscopic Myotomy POEM for Treating Gastrointestinal Motility Disorders

What this Trial Is About

This research aims to collect prospective data on patients with gastrointestinal motility disorders receiving peroral endoscopic myotomy POEM as part of their standard medical care. The study focuses on conditions such as achalasia, diffuse esophageal spasm, gastroparesis, swallowing disorder, and Zenkers diverticulum. No experimental treatments will be administered, and the goal is to evaluate the clinical utility of POEM procedures over time. Participants will undergo one of three types of POEM procedures according to standard care Esophageal POEM E-POEM, Gastric POEM G-POEM, or Zenkers diverticulum POEM Z-POEM. Data will be collected during their routine treatment without altering their care plan. The study plans to enroll 600 subjects over 4 to 5 years and will monitor outcomes related to reflux rates, long-term clinical efficacy, and recurrence rates over a 12-month period following the procedures. During the study, participants will receive usual medical assessments and care. Researchers will collect information on post-procedure reflux, symptom improvement, and disease management effectiveness up to one year after treatment. No additional experimental interventions will be performed, and the total participation involves observation and data recording alongside standard clinical follow-up provided by the participants healthcare providers.

Prospective Evaluation of the Clinical Utility of Peroral Endoscopic Myotomy for Gastrointestinal Motility Disorders