Actively Recruiting
Prospective Evaluation of Pathways for Preterm Birth
Led by John O'Brien, MD · Updated on 2025-07-02
240
Participants Needed
1
Research Sites
225 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This is a single center, prospective cohort study of pregnant patients at high risk for spontaneous preterm birth: patient's with history of spontaneous preterm birth, patient's with a short cervix and patient's symptomatic for preterm birth will be included. A control cohort of nulliparous patients without a short cervix will be recruited to provide baseline data. Plan to enroll 240 patients identified through our ultrasound unit with goal of 60 patients in each group.
CONDITIONS
Official Title
Prospective Evaluation of Pathways for Preterm Birth
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Maternal age from 18 to 45 years of age.
- Singleton gestation.
You will not qualify if you...
- Treatment with vaginal progesterone or intramuscular progestogen within the previous 4 weeks.
- History of congestive heart failure, chronic renal failure, or uncontrolled diabetes mellitus, or diabetes mellitus with evidence of end organ dysfunction secondary to vascular disease.
- Current pregnancy with a major fetal anomaly or known chromosomal abnormality.
- Marked uterine anatomic malformation that may alter pregnancy duration such as a septated uterus, unicornuate uterus, or uterine didelphys.
- Considered not capable or unwilling to undergo study procedures and requirements.
- Symptomatic with vaginal bleeding at enrollment visit.
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
University of Kentucky
Lexington, Kentucky, United States, 40506
Actively Recruiting
Research Team
C
Cynthia Cockerham
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
4
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