Actively Recruiting
Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors
Led by The New York Proton Center · Updated on 2026-04-13
1800
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of different doses and schedules of Proton Therapy for patients with tumors that have returned or newly appeared after prior radiation treatment. Traditional photon radiation therapy exposes healthy tissues to radiation, limiting the dose that can be safely given. Proton therapy may better target tumors while sparing healthy tissue, potentially allowing for more effective treatment of recurrent tumors in patients who have previously received radiation to the same area. The study includes various patient groups with different tumor types, such as central nervous system, head and neck, breast, thoracic, gastrointestinal, genitourinary, and gynecological cancers. All participants receive Pencil Beam Scanning Proton Therapy, which is being compared to historical outcomes from traditional photon therapy. The study includes both prospective phase II trials and registry cohorts, with minimum intervals between radiation courses and specific criteria for each tumor group. Participants are monitored for treatment-related side effects and tumor control outcomes, with primary focus on adverse events of grade 3 or higher within one year after completing reirradiation. Secondary outcomes include survival rates, progression-free survival, and patient-reported outcomes using specific symptom assessment forms. Follow-up includes assessments at 90 days, one year, two years, and up to five years. Participants undergo clinical evaluations, imaging, and laboratory tests as needed throughout the study period.
CONDITIONS
Brief Title
Prospective Evaluation of Pencil Beam Scanning Proton Therapy for Previously Irradiated Tumors
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Patient provides study specific informed consent prior to study entry
- Documented history and physical exam within 90 days prior to registration
- ECOG performance status 0, 1, or 2 within 90 days prior to registration
You will not qualify if you...
- Non malignant systemic disease that would prevent study treatment or required follow up
- Prior invasive non-study malignancy unless disease free for 3 or more years
- History of active connective tissue disorder such as systemic lupus erythematosus, scleroderma, dermatomyositis, or xeroderma pigmentosum
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of proton therapy as per individual treatment plan
Participants receive Pencil Beam Scanning Proton Therapy for reirradiation of recurrent or new primary tumors in previously irradiated areas.
Multiple visits for radiation therapy sessions as scheduled
Duration - Up to 5 years
Participants are monitored for treatment-related adverse events and outcomes for up to 5 years after completion of reirradiation.
Regular follow-up visits as scheduled over 5 years
Trial Site Locations
Total: 1 location
1
The New York Proton Center
New York, New York, United States, 10035
Actively Recruiting
Research Team
R
Ryan Holder, BS
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NON_RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
8
Similar Trials
Frequently Asked Questions
Have more questions? Get in touch with our team for quick support
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here