Actively Recruiting
Prospective Evaluation of the Prognostic Impact of Measurable Residual Disease (MRD) Within a Phase III Study Comparing a Fixed Duration Therapy Versus Continuous Therapy With Daratumumab, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma Requiring a First Salvage Treatment.
Led by Assistance Publique - Hôpitaux de Paris · Updated on 2024-12-06
260
Participants Needed
1
Research Sites
345 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
We propose to conduct an ancillary prospective evaluation of the impact of Dara-Len-Dex discontinuation after 2 years, on the persistence of MRD negativity in patients that were MRD negative at 2 years.
CONDITIONS
Official Title
Prospective Evaluation of the Prognostic Impact of Measurable Residual Disease (MRD) Within a Phase III Study Comparing a Fixed Duration Therapy Versus Continuous Therapy With Daratumumab, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma Requiring a First Salvage Treatment.
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients (≥ 18 years old) who are included in the CONFIRM phase III trial (ClinicalTrials.gov Identifier: NCT03836014).
- Subject that are still under therapy at 2 years (+/- 3 month) after randomization, either in the fixed duration therapy group or in the continuous therapy group of the CONFIRM protocol
- Subject in complete response at 2 years (+/- 3 month) after randomization.
- Signed informed consent
- Affiliation to a social security system or equivalent
You will not qualify if you...
- None
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Department of Hematology, Hospital Saint Antoine
Paris, France, 75012
Actively Recruiting
Research Team
M
Mohamad MOHTY, PUPH
CONTACT
F
Florent MALARD, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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