Actively Recruiting
Prospective External Control Cohort In Patients With Newly Diagnosed Advanced or Metastatic EGFR Mutant Non-Small Cell Lung Cancer
Led by N-Power Medicine · Updated on 2026-03-03
130
Participants Needed
6
Research Sites
199 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this study is to build a prospective cohort in patients with locally advanced or metastatic NSCLC with common EGFR mutations. In NPM-002, there will be standardized data collection at baseline, on-treatment and at discontinuation of therapy. Patients who enroll prior to initiation of osimertinib treatment (\~30%) will undergo imaging with standardized intervals.
CONDITIONS
Official Title
Prospective External Control Cohort In Patients With Newly Diagnosed Advanced or Metastatic EGFR Mutant Non-Small Cell Lung Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Be 18 years of age or older at the time of informed consent
- Have a confirmed diagnosis of EGFR mutant (EGFR exon 19del or EGFR exon 21 L858R) locally advanced or metastatic NSCLC diagnosed on or after January 1, 2024
You will not qualify if you...
- Have an ECOG performance status of 2 or higher at diagnosis of advanced or metastatic NSCLC
- Have prior treatment with osimertinib, amivantamab, or lazertinib
- Additional exclusion criteria may be applied according to the COPERNICUS SAP for selection and analysis of external controls
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 6 locations
1
Pacific Cancer Care
Monterey, California, United States, 93940
Actively Recruiting
2
Bayhealth Cancer Center- Kent
Dover, Delaware, United States, 19901
Actively Recruiting
3
Bayhealth Cancer Center- Sussex
Milford, Delaware, United States, 19963
Actively Recruiting
4
Northwest Oncology & Hematology
Elk Grove Village, Illinois, United States, 60007
Actively Recruiting
5
Lankenau Medical Center
Paoli, Pennsylvania, United States, 19301
Not Yet Recruiting
6
Oncology Consultants, P.A.
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
N
N-Power Medicine Support
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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