Actively Recruiting

Age: 18Years +
All Genders
NCT07232680

Prospective Immuno-Radiomic Profiling in Nasopharyngeal Carcinoma Treated With Proton or Photon Chemoradiotherapy

Led by Cheng-En Hsieh · Updated on 2025-11-24

500

Participants Needed

1

Research Sites

455 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

To prospectively investigate and integrate radiomic and immunologic signatures in patients with nasopharyngeal carcinoma (NPC) treated with either proton or photon radiotherapy, with the aim of identifying biomarkers associated with treatment response, toxicity, and long-term outcomes.

CONDITIONS

Official Title

Prospective Immuno-Radiomic Profiling in Nasopharyngeal Carcinoma Treated With Proton or Photon Chemoradiotherapy

Who Can Participate

Age: 18Years +
All Genders

Eligibility Criteria

Eligible

You may qualify if you...

  • Willingness to provide written informed consent.
  • Pathologically confirmed diagnosis of nasopharyngeal carcinoma.
  • Age 18 years or older.
  • ECOG performance status 0-1.
  • Patients with AJCC v.9 stage I-III disease who undergo chemoradiotherapy.
  • Adequate bone marrow, liver, and renal function within 4 weeks before study registration, including hemoglobin 2 9.0 g/dL, ANC 2 1,000/mm3, platelet count 2 50,000/bcL, total bilirubin < 2.5 mg/dL, serum albumin >2.8 g/dL, and serum creatinine 2 1.5 mg/dL.
Not Eligible

You will not qualify if you...

  • Presence of distant metastasis.
  • Patients with AJCC v.9 cT1N0M0 disease who undergo radiotherapy alone.
  • Synchronous or prior invasive malignancy, unless disease-free for at least 2 years.
  • Prior radiotherapy to the head and neck region.
  • Presence of severe major organ dysfunction.
  • Pregnant women or women of childbearing potential unwilling to use medically acceptable contraception.

AI-Screening

AI-Powered Screening

Complete this quick 3-step screening to check your eligibility

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Trial Site Locations

Total: 1 location

1

Chang Gung Memorial Hospital at Linkou

Taoyuan City, Taiwan, Taiwan, 333

Actively Recruiting

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Research Team

R

Rodney Cheng-En Hsieh, MD, PhD

CONTACT

How is the study designed?

Study Type

OBSERVATIONAL

Masking

N/A

Allocation

N/A

Model

N/A

Primary Purpose

N/A

Number of Arms

2

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