Study to Improve and Test a New Model Predicting Progression of Adolescent Idiopathic Scoliosis in Patients Aged 10 to 15

What this Trial Is About

Scoliosis is a three-dimensional deformity that changes the spines shape and position. The most common type, adolescent idiopathic scoliosis AIS, affects mainly young adolescent females and can require bracing or surgery to prevent worsening. Researchers have developed a predictive model using 3D spinal measurements to better estimate curve progression in AIS. This study aims to refine and test this model in a larger group to help guide treatment decisions more accurately. The study uses a new low-dose biplanar X-ray system EOS to take stereo-radiographs and create 3D reconstructions of the spine and pelvis. These images help measure vertebrae, disks, and pelvic geometry in detail. Patients may receive usual treatments like bracing or surgery if needed, with bracing compliance monitored using special sensors. Surgical patients will have their data analyzed but leave the study after surgery. The goal is to validate the model by comparing the new 3D measurements with traditional methods over time. Participants will be followed for up to 24 months with visits ideally every 6 months, including physical exams, growth and maturity assessments, and X-rays without braces at least annually. The study collects detailed data at each visit to track scoliosis severity and curve changes using 3D spine reconstructions. Researchers will analyze these measurements to improve predictions of scoliosis progression and help identify which patients need early treatment to avoid surgery.

Prospective Multicenter Evaluation of a New Predictive Model for the Progression of Adolescent Idiopathic Scoliosis