What is this study trying to find out about retained products of conception?

This study is evaluating if using medication and waiting for the right time to perform surgery can reduce the risk of uterine scarring compared to immediate surgery in women with retained products of conception. The goal is to protect fertility by lowering complications after treatment. It is sponsored by The Third Xiangya Hospital of Central South University.

Who may be eligible for this retained products of conception clinical trial?

Women aged 18 to 45 with a clinical diagnosis of retained products of conception and an ultrasound showing a lesion at least 0.5 cm may be eligible. Women with active bleeding needing immediate surgery, obvious infection, or severe organ dysfunction are excluded. Please review eligibility criteria for more details.

Is there any cost to participate in this retained products of conception clinical trial?

Study-related care, including the study procedures and all trial visits, is provided at no cost. Personal travel expenses may vary and might not be covered. Participants should plan accordingly.

Actively Recruiting

Age: 18Years - 45Years

FEMALE

Healthy Volunteers

ID07421895

Observational Study of Treatment Strategies for Retained Products of Conception in Women Aged 18 to 45

Led by The Third Xiangya Hospital of Central South University · Updated on 2026-02-19

600

Participants Needed

Research Sites

261 weeks

Total Duration

AI-Summary

What this Trial Is About

Researchers are exploring the best treatment approach for retained products of pregnancy, a condition where tissue remains in the uterus after pregnancy. This study aims to see if managing the condition with medication and waiting for the right time to perform surgery reduces the risk of intrauterine adhesions, which can affect fertility. The study is observational and compares this drug-assisted expectant management to immediate surgical treatment. Participants will be assigned to one of two groups one group will have immediate hysteroscopic removal of pregnancy tissue under anesthesia, while the other group will receive medication and careful monitoring until surgery is needed or the condition resolves. The medication includes hormone therapy and herbal treatments, with regular ultrasound and blood tests to guide timing for surgery if necessary. During the study, participants will be closely monitored with ultrasound scans and blood tests to assess healing and complications. Researchers will track outcomes such as the presence of uterine adhesions three months after treatment, need for additional surgery, pregnancy rates within one year, bleeding, infections, blood loss during surgery, and uterine lining thickness. Participants will be followed up to one year after treatment to observe these outcomes and overall reproductive health.

CONDITIONS

Brief Title

A Prospective Multicenter Observational Real-world Study of Retained Products of Conception

Who Can Participate

Age: 18Years - 45Years

FEMALE

Healthy Volunteers

Eligibility Criteria

You may qualify if you...

Clinical diagnosis of retained products of conception
Ultrasound showing a lesion with a maximum diameter of at least 0.5 cm
Female participants aged 18 to 45 years

You will not qualify if you...

Active bleeding requiring immediate surgical intervention
Obvious infection
Severe organ dysfunction, including coagulation dysfunction

Research Team

Dabao MD

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