Multicenter Study on BASIS Technique for Treating Acute Large Vessel Strokes Caused by Intracranial Atherosclerosis

What this Trial Is About

Researchers are evaluating the safety and effectiveness of the BASIS technique, a specialized balloon angioplasty combined with distal protection by a stent retriever, in treating acute large vessel occlusion strokes caused by intracranial atherosclerosis. This multicenter, prospective, observational single-arm study aims to gather detailed data on procedure times, recanalization success, complications, and patient outcomes to improve treatment methods for complex stroke lesions. The study involves using the BASIS technique during endovascular therapy, which includes balloon angioplasty under the protection of a stent retriever for blood vessel reopening. Surgeons follow a stepwise procedure involving microcatheter placement, balloon inflation, thrombus removal with suction techniques, and repeated angiographic checks to ensure clearance of blockages. The study has no control group and allows different remedial treatments as needed during the procedure. Participants will be monitored for complications such as branch occlusion, vessel dissection, rupture, thrombus displacement, and symptomatic intracranial hemorrhage. Key outcomes measured include modified Rankin Scale mRS scores at 90 days and first pass effect during the approximately three-hour surgery. Follow-up over three months records mortality, functional recovery, and residual vessel narrowing. The study tracks detailed intraoperative and postoperative data to assess the techniques impact on safety and prognosis.

A Prospective Multicenter Registry Study on BASIS Technique for Endovascular Therapy of Acute Large Vessel Occlusion Strokes Due to Intracranial Atherosclerotic Disease