Actively Recruiting
Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients
Led by PrECOG, LLC. · Updated on 2026-03-27
538
Participants Needed
146
Research Sites
254 weeks
Total Duration
On this page
Sponsors
P
PrECOG, LLC.
Lead Sponsor
E
ECOG-ACRIN Cancer Research Group
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of the study is to collect data on patients treated outside of a clinical trial (in routine clinical practice) with standard of care osimertinib with or without chemotherapy in Epidermal Growth Factor Receptor (EGFR)-mutant Non-Small Cell Lung Cancer (NSCLC) to better understand the safety and effectiveness of these standard of care regimens.
CONDITIONS
Official Title
Prospective Non-Interventional Study Comparing Osimertinib +/- Chemotherapy for EGFR-Mutated NSCLC Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Pathologically confirmed diagnosis of non-small cell lung cancer (NSCLC).
- Advanced disease stage IIIB (not suitable for definitive multi-modality therapy), IIIC, or IV, including local or distant recurrence after prior Stage I-III.
- Tumor must have a somatic activating sensitizing EGFR mutation (e.g., Exon 19 deletion, L858R, E709X, G719X, exon 19 insertions, L861Q, S768I).
- Prior chemotherapy and/or immunotherapy before EGFR mutation identification allowed up to 45 days before study registration.
- Prior osimertinib treatment allowed if within 30 days before study registration; prior treatment with other EGFR TKIs not allowed.
- Not participating in EA5182 or any other cancer treatment clinical trial.
- Osimertinib or osimertinib plus chemotherapy/immunotherapy as first-line treatment cannot be part of a clinical trial.
- Prior radiation therapy for this disease is allowed.
- Adults aged 18 years or older.
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 146 locations
1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35294
Actively Recruiting
2
Mercy Clinic Fort Smith Communities
Fort Smith, Arkansas, United States, 72903
Actively Recruiting
3
Mercy Research
Fort Smith, Arkansas, United States, 72903
Actively Recruiting
4
Fowler Family Cancer Center - Jonesboro
Jonesboro, Arkansas, United States, 72401
Actively Recruiting
5
Stanford Cancer Center Emeryville
Emeryville, California, United States, 94608
Actively Recruiting
6
Stanford Cancer Institute Palo Alto
Palo Alto, California, United States, 94304
Actively Recruiting
7
Stanford Cancer Center South Bay
San Jose, California, United States, 95124
Actively Recruiting
8
John Muir Health
Walnut Creek, California, United States, 94598
Actively Recruiting
9
Bayhealth
Dover, Delaware, United States, 19901
Actively Recruiting
10
Satellite of Bayhealth Sussex
Milford, Delaware, United States, 19901
Actively Recruiting
11
Sibley Johns Hopkins University
Washington D.C., District of Columbia, United States, 20016
Actively Recruiting
12
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Liberty County Cancer Care
Hinesville, Georgia, United States, 31313
Actively Recruiting
13
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: Regional Cancer Care
Jesup, Georgia, United States, 31545
Actively Recruiting
14
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
Savannah, Georgia, United States, 31405
Actively Recruiting
15
Advocate Good Shepherd Hospital
Barrington, Illinois, United States, 60010
Actively Recruiting
16
Northwestern University
Chicago, Illinois, United States, 60611
Actively Recruiting
17
John H Stroger Jr Hospital of Cook County
Chicago, Illinois, United States, 60612
Actively Recruiting
18
Advocate Illinois Masonic Medical Center
Chicago, Illinois, United States, 60657
Actively Recruiting
19
Northwestern Medicine Cancer Center Kishwaukee
DeKalb, Illinois, United States, 60115
Actively Recruiting
20
Northwestern Medicine Cancer Center Delnor
Geneva, Illinois, United States, 60134
Actively Recruiting
21
Northwestern Medicine Glenview Outpatient Center
Glenview, Illinois, United States, 60026
Actively Recruiting
22
Northwestern Medicine Grayslake Outpatient Center
Grayslake, Illinois, United States, 60030
Actively Recruiting
23
Advocate South Suburban Hospital
Hazel Crest, Illinois, United States, 60429
Actively Recruiting
24
Northwestern Medicine Lake Forest Hospital
Lake Forest, Illinois, United States, 60045
Actively Recruiting
25
Carle Cancer Institute Normal
Normal, Illinois, United States, 61761
Actively Recruiting
26
Advocate Christ Medical Center
Oak Lawn, Illinois, United States, 60453
Actively Recruiting
27
Northwestern Medicine Orland Park
Orland Park, Illinois, United States, 60462
Actively Recruiting
28
Advocate Lutheran General Hospital
Park Ridge, Illinois, United States, 60068
Actively Recruiting
29
Carle Founation Hospital
Urbana, Illinois, United States, 61801
Actively Recruiting
30
Northwestern Medicine Cancer Center Warrenville
Warrenville, Illinois, United States, 60555
Actively Recruiting
31
University of Maryland Greenebaum Comprehensive Cancer Center
Baltimore, Maryland, United States, 21201
Actively Recruiting
32
Greater Baltimore Medical Center
Baltimore, Maryland, United States, 21204
Actively Recruiting
33
Tufts Medical Center
Boston, Massachusetts, United States, 02111
Actively Recruiting
34
Lowell General Hosptial
Lowell, Massachusetts, United States, 01854
Actively Recruiting
35
Tufts Medical Center Cancer Center Stoneham
Stoneham, Massachusetts, United States, 02180
Actively Recruiting
36
Minnesota Oncology - Burnsville
Burnsville, Minnesota, United States, 55337
Actively Recruiting
37
Cambridge Medical Center
Cambridge, Minnesota, United States, 55008
Actively Recruiting
38
Mercy Hospital
Coon Rapids, Minnesota, United States, 55433
Actively Recruiting
39
Fairview Southdale Hospital
Edina, Minnesota, United States, 55435
Actively Recruiting
40
Fairview Clinics and Surgery Center Maple Grove
Maple Grove, Minnesota, United States, 55369
Actively Recruiting
41
Minnesota Oncology Hematology PA-Maplewood
Maplewood, Minnesota, United States, 55109
Actively Recruiting
42
Saint John's Hospital - Healtheast
Maplewood, Minnesota, United States, 55109
Actively Recruiting
43
Abbott-Northwestern Hospital
Minneapolis, Minnesota, United States, 55407
Actively Recruiting
44
Hennepin County Medical Center
Minneapolis, Minnesota, United States, 55415
Actively Recruiting
45
Health Partners Inc.
Minneapolis, Minnesota, United States, 55454
Actively Recruiting
46
Monticello Cancer Center
Monticello, Minnesota, United States, 55362
Actively Recruiting
47
New Ulm Medical Center
New Ulm, Minnesota, United States, 56073
Actively Recruiting
48
Fairview Northland Medical Center
Princeton, Minnesota, United States, 55371
Actively Recruiting
49
North Memorial Medical Health Center
Robbinsdale, Minnesota, United States, 55422
Actively Recruiting
50
Park Nicollet Clinic - Saint Louis Park
Saint Louis Park, Minnesota, United States, 55416
Actively Recruiting
51
Metro MN
Saint Louis Park, Minnesota, United States, 55426
Actively Recruiting
52
Regions Hospital
Saint Paul, Minnesota, United States, 55101
Actively Recruiting
53
United Hospital
Saint Paul, Minnesota, United States, 55102
Actively Recruiting
54
Saint Francis Regional Medical Center
Shakopee, Minnesota, United States, 55379
Actively Recruiting
55
Lakeview Hospital
Stillwater, Minnesota, United States, 55082
Actively Recruiting
56
Ridgeview Medical Center
Waconia, Minnesota, United States, 55387
Actively Recruiting
57
Rice Memorial Hospital
Willmar, Minnesota, United States, 56201
Actively Recruiting
58
Minnesota Oncology Hematology PA-Woodbury
Woodbury, Minnesota, United States, 55125
Actively Recruiting
59
Fairview Lakes Medical Center
Wyoming, Minnesota, United States, 55092
Actively Recruiting
60
Baptist Memorial Hospital and Cancer Center - Golden Triangle
Columbus, Mississippi, United States, 39705
Actively Recruiting
61
Baptist Cancer Center - Grenada
Grenada, Mississippi, United States, 38901
Actively Recruiting
62
Jackson Oncology Associates PLLC
Jackson, Mississippi, United States, 39202
Actively Recruiting
63
Mississippi Baptist Medical Center
Jackson, Mississippi, United States, 39202
Actively Recruiting
64
Baptist Memorial Hospital and Cancer Center - Union
New Albany, Mississippi, United States, 38652
Actively Recruiting
65
Baptist Memorial Hospital and Cancer Center - Oxford
Oxford, Mississippi, United States, 38655
Actively Recruiting
66
Baptist Memorial Hospital and Cancer Center - Desoto
Southhaven, Mississippi, United States, 38671
Actively Recruiting
67
Mercy Clinic Joplin, LLC
Joplin, Missouri, United States, 64804
Actively Recruiting
68
Mercy Clinic Cancer and Hematology
Rolla, Missouri, United States, 65401
Actively Recruiting
69
Mercy Clinic Springfield Communities
Springfield, Missouri, United States, 65804
Actively Recruiting
70
Mercy Clinic East Communities
St Louis, Missouri, United States, 63128
Actively Recruiting
71
Mercy Clinic East Communities
St Louis, Missouri, United States, 63141
Actively Recruiting
72
Virtua Samson Cancer Center
Moorestown, New Jersey, United States, 08057
Actively Recruiting
73
Atlantic Health Cancer Consortium Community Oncology Research Program
Morristown, New Jersey, United States, 07960
Actively Recruiting
74
Morristown Medical Center
Morristown, New Jersey, United States, 07960
Actively Recruiting
75
Rutgers Cancer Institute of New Jersey
New Brunswick, New Jersey, United States, 08903
Actively Recruiting
76
The Valley Hospital - Luckow Pavilion
Paramus, New Jersey, United States, 07652
Actively Recruiting
77
Sidney Kimmel Cancer Center Washington Township
Sewell, New Jersey, United States, 08080
Actively Recruiting
78
Overlook Medical Center
Summit, New Jersey, United States, 07901
Actively Recruiting
79
Virtua Voorhees
Voorhees Township, New Jersey, United States, 08043
Actively Recruiting
80
The Cancer Institute at St. Francis Hospital
East Hills, New York, United States, 11548
Actively Recruiting
81
Montefiore
New York, New York, United States, 10467
Actively Recruiting
82
SUNY Upstate Medical University
Syracuse, New York, United States, 13210
Actively Recruiting
83
Montefiore Medical Center-Einstein Campus
The Bronx, New York, United States, 10461
Actively Recruiting
84
Good Samaritan University Hospital
West Islip, New York, United States, 11795
Actively Recruiting
85
UNC Pardee Cancer Center
Hendersonville, North Carolina, United States, 28791
Actively Recruiting
86
FirstHealth of the Carolinas-Moore Regional Hospital
Pinehurst, North Carolina, United States, 28374
Actively Recruiting
87
Aultman
Canton, Ohio, United States, 44710
Actively Recruiting
88
Miami Valley Hospital South
Centerville, Ohio, United States, 45459
Actively Recruiting
89
Miami Valley Hospital North
Englewood, Ohio, United States, 45415
Actively Recruiting
90
Atrium Medical Center-Middletown Regional Hospital
Franklin, Ohio, United States, 45005
Actively Recruiting
91
Miami Valley Cancer Care and Infusion
Greenville, Ohio, United States, 45331
Actively Recruiting
92
Upper Valley Medical Center
Troy, Ohio, United States, 45373
Actively Recruiting
93
Mercy Clinic Oklahoma Communities, Inc.
Oklahoma City, Oklahoma, United States, 73120
Actively Recruiting
94
Geisinger Medical Center
Danville, Pennsylvania, United States, 17822
Actively Recruiting
95
Geisinger Medical Center-Cancer Center Hazleton
Hazleton, Pennsylvania, United States, 18201
Actively Recruiting
96
Geisinger Medical Oncology-Lewisburg
Lewisburg, Pennsylvania, United States, 17837
Actively Recruiting
97
Lewistown Hospital
Lewistown, Pennsylvania, United States, 17044
Actively Recruiting
98
Lankenau Medical Center
Paoli, Pennsylvania, United States, 19301
Actively Recruiting
99
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
Actively Recruiting
100
Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States, 19107
Actively Recruiting
101
Jefferson Torresdale Hospital
Philadelphia, Pennsylvania, United States, 19114
Actively Recruiting
102
Einstein Medical Center
Philadelphia, Pennsylvania, United States, 19141
Actively Recruiting
103
Allegheny General Hospital
Pittsburgh, Pennsylvania, United States, 15212
Actively Recruiting
104
Geisinger Cancer Services-Pottsville
Pottsville, Pennsylvania, United States, 17901
Actively Recruiting
105
Community Medical Center
Scranton, Pennsylvania, United States, 18510
Actively Recruiting
106
Geisinger Medical Group
State College, Pennsylvania, United States, 16801
Actively Recruiting
107
Geisinger Wyoming Valley/Henry Cancer Center
Wilkes-Barre, Pennsylvania, United States, 18711
Actively Recruiting
108
Asplundh Cancer Pavilion
Willow Grove, Pennsylvania, United States, 19090
Actively Recruiting
109
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: SJC Bluffton Campus
Bluffton, South Carolina, United States, 29910
Actively Recruiting
110
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler: South Carolina Cancer Specialists
Hilton Head Island, South Carolina, United States, 29926
Actively Recruiting
111
Baptist Memorial Hospital and Cancer Center - Collierville
Collierville, Tennessee, United States, 38017
Actively Recruiting
112
Baptist Memorial Hospital and Cancer Center - Memphis
Memphis, Tennessee, United States, 38120
Actively Recruiting
113
Baptist Memorial Hospital for Women
Memphis, Tennessee, United States, 38120
Actively Recruiting
114
Vanderbilt University
Nashville, Tennessee, United States, 37232
Actively Recruiting
115
UT Southwest
Dallas, Texas, United States, 75235
Actively Recruiting
116
JPS Oncology & Infusion Center
Fort Worth, Texas, United States, 76104
Actively Recruiting
117
ThedaCare Regional Cancer Center
Appleton, Wisconsin, United States, 54911
Actively Recruiting
118
ThedaCare Regional Medical Center - Appleton
Appleton, Wisconsin, United States, 54911
Actively Recruiting
119
ThedaCare Cancer Care - Berlin
Berlin, Wisconsin, United States, 54923
Actively Recruiting
120
Aurora Cancer Care-Southern Lakes VLCC
Burlington, Wisconsin, United States, 53105
Actively Recruiting
121
Aurora Saint Luke's South Shore
Cudahy, Wisconsin, United States, 53110
Actively Recruiting
122
AHC Germantown Health Center
Germantown, Wisconsin, United States, 53022
Actively Recruiting
123
Aurora Cancer Care-Grafton
Grafton, Wisconsin, United States, 53024
Actively Recruiting
124
Aurora BayCare Medical Center
Green Bay, Wisconsin, United States, 54311
Actively Recruiting
125
Mercyhealth Hospital and Cancer Center - Janesville
Janesville, Wisconsin, United States, 53548
Actively Recruiting
126
Aurora Cancer Care-Kenosha South
Kenosha, Wisconsin, United States, 53142
Actively Recruiting
127
Gundersen Lutheran Medical Foundation
La Crosse, Wisconsin, United States, 54601
Actively Recruiting
128
University of Wisconsin Carbone Cancer Center
Madison, Wisconsin, United States, 53715
Actively Recruiting
129
Marshfield Medical Center
Marshfield, Wisconsin, United States, 54449
Actively Recruiting
130
Aurora Cancer Care-Milwaukee
Milwaukee, Wisconsin, United States, 53209
Actively Recruiting
131
Aurora NCORP
Milwaukee, Wisconsin, United States, 53215
Actively Recruiting
132
Aurora Saint Luke's Medical Center
Milwaukee, Wisconsin, United States, 53215
Actively Recruiting
133
Aurora West Allis Medical Center
Milwaukee, Wisconsin, United States, 53227
Actively Recruiting
134
Aurora Sinai Medical Center
Milwaukee, Wisconsin, United States, 53233
Actively Recruiting
135
ThedaCare Regional Medical Center - Neenah
Neenah, Wisconsin, United States, 54956
Actively Recruiting
136
ThedaCare Cancer Care - New London
New London, Wisconsin, United States, 54961
Actively Recruiting
137
ThedaCare Cancer Care - Oshkosh
Oshkosh, Wisconsin, United States, 54904
Actively Recruiting
138
Vince Lombardi Cancer Clinic-Oshkosh
Oshkosh, Wisconsin, United States, 54904
Actively Recruiting
139
Aurora Cancer Care-Racine
Racine, Wisconsin, United States, 53406
Actively Recruiting
140
ThedaCare Cancer Care - Shawano
Shawano, Wisconsin, United States, 54166
Actively Recruiting
141
Vince Lombardi Cancer Clinic-Sheboygan
Sheboygan, Wisconsin, United States, 53081
Actively Recruiting
142
Aurora Medical Center in Summit
Summit, Wisconsin, United States, 53066
Actively Recruiting
143
Vince Lombardi Cancer Clinic-Two Rivers
Two Rivers, Wisconsin, United States, 54241
Actively Recruiting
144
ProHealth
Waukesha, Wisconsin, United States, 53022
Actively Recruiting
145
ThedaCare Cancer Care - Waupaca
Waupaca, Wisconsin, United States, 54981
Actively Recruiting
146
Aurora Cancer Care-Milwaukee West
Wauwatosa, Wisconsin, United States, 53226
Actively Recruiting
Research Team
K
Karen Fitzpatrick, RN
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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