Actively Recruiting
A Prospective, Randomized Parallel Group Study of the Efficacy of Vancomycin Administered Through Intraarticular Injection Versus Intraosseous Injection Versus Intravenous Infusion in Patients Undergoing Total Knee Arthroplasty
Led by University of California, San Diego · Updated on 2025-12-15
30
Participants Needed
1
Research Sites
237 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Periprosthetic joint infection (PJI) is a national health crisis and leads to very poor outcomes for patients undergoing elective joint replacement. Within the realm of elective total knee arthroplasty (TKA), various methods of infection prophylaxis are in place. These include sterile precautions, would/tissue handling, and antibiotic prophylaxis. With respect to the latter, various approaches have been utilized including intravenous and intraosseous administration of vancomycin, preoperatively. Intraosseous administration does require another wound and a specific device to administer. We proposed that intraarticular injection of vancomycin is non-inferior to intraosseous administration, thus reducing wounds, time, and cost.
CONDITIONS
Official Title
A Prospective, Randomized Parallel Group Study of the Efficacy of Vancomycin Administered Through Intraarticular Injection Versus Intraosseous Injection Versus Intravenous Infusion in Patients Undergoing Total Knee Arthroplasty
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Any patient over the age of 18 years of age receiving treatment at UC San Diego Health
- Undergoing primary unilateral total knee arthroplasty
- Ability to provide consent
You will not qualify if you...
- Previous surgery on the knee (except arthroscopy)
- Body mass index (BMI) greater than 35
- Allergy or contraindication to vancomycin, cefepime, or cefazolin
- Diabetes with A1c greater than 7.5% unless controlled fructosamine is documented
- Immunocompromised or immunosuppressed conditions (including HIV, Hepatitis C, end stage renal disease, post-transplant status, chemotherapy or radiation within 6 months, or use of immunomodulating medications)
- History of active infections
- History of chronic kidney disease
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of California, San Diego
San Diego, California, United States, 92093
Actively Recruiting
Research Team
D
Dominic Baun
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
3
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