Comparing SPHERIKA and ORIGIN Prostheses for Total Knee Replacement Using Kinematic Alignment

What this Trial Is About

Researchers are comparing two types of total knee prostheses designed for the kinematic alignment technique in patients needing initial total knee replacement due to knee osteoarthritis. The study aims to assess how patients perceive these prostheses, alongside clinical, imaging, gait biomechanics, and knee muscle strength outcomes. The kinematic alignment technique seeks to better replicate each patients natural knee anatomy compared to traditional mechanical alignment, potentially reducing residual symptoms and improving patient experience. Participants will undergo total knee arthroplasty using one of two prostheses the made-to-measure Origin4 prosthesis or the generic but kinematic alignment-optimized SpheriKA4 prosthesis. The study randomly assigns patients to receive either prosthesis through a single-masked design. The interventions involve surgical implantation of the prosthesis using the kinematic alignment approach. Participants will be evaluated before surgery, 45 days after surgery, and at 1 and 2 years post-surgery. Assessments include the forgotten joint score to measure joint perception, lower limb frontal alignment via imaging, walking ability, and knee muscle strength. The study will monitor these outcomes over two years to compare the prostheses performance and patient satisfaction.

Prospective Randomized Study Comparing the SpheriKA® (MEDACTA) and Origin® (SYMBIOS) Prostheses During Total Knee Replacement Using the Kinematic Alignment Technique