Actively Recruiting
A Prospective Registry for Patients at High-Risk for Pancreatic Cancer
Led by Mayo Clinic · Updated on 2026-03-10
5000
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are studying people at high risk for pancreatic ductal adenocarcinoma (PDAC) to develop and validate early detection tests. This research uses advanced machine learning algorithms to analyze medical databases and images to identify early stages of pancreatic cancer or those at risk. The study also aims to create a platform to develop early detection methods for PDAC. Participants are grouped based on genetic mutations or family history related to pancreatic cancer risk. Blood samples will be collected at enrollment and during follow-up visits, and pancreatic juice may be collected during certain clinical procedures when appropriate. Patients in one risk group will be offered research MRI scans at baseline and every three years. Clinical imaging results from standard care will also be used. Participants will provide biospecimens like blood and pancreatic juice, undergo imaging assessments, and have their medical data collected for up to 10 years. The study monitors these samples and images to improve early detection of pancreatic cancer. Participation involves consent and periodic visits or procedures as recommended by clinical care and study protocol.
CONDITIONS
Brief Title
A Prospective Registry for Patients at High-Risk for Pancreatic Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Able to provide written informed consent
- Meets criteria as a High-Risk Individual as defined by protocol
You will not qualify if you...
- Personal history of pancreatic ductal adenocarcinoma (PDAC)
- History of total pancreatectomy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Baseline and every 3 years for up to 10 years
Participants undergo diagnostic imaging including research and clinical MRIs with contrast and MRCP to assess pancreatic health.
Imaging visits at baseline and at 3-year intervals
Duration - Up to 10 years
Participants provide blood samples at enrollment and serially depending on tier classification, and pancreatic juice samples during clinically indicated endoscopic procedures if applicable.
Blood draws at enrollment and follow-up visits; pancreatic juice collected during relevant endoscopic procedures
Duration - Up to 10 years
Participants are monitored over time through collection of biospecimens and imaging data to track pancreatic cancer risk.
Ongoing visits as needed for biospecimen collection and imaging
Trial Site Locations
Total: 1 location
1
Mayo Clinic in Rochester
Rochester, Minnesota, United States, 55905
Actively Recruiting
Research Team
C
Clinical Trials Referral Office
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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