Actively Recruiting
Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure
Led by Semmelweis University · Updated on 2025-06-11
1000
Participants Needed
7
Research Sites
312 weeks
Total Duration
On this page
Sponsors
S
Semmelweis University
Lead Sponsor
S
Siemens Corporation, Corporate Technology
Collaborating Sponsor
AI-Summary
What this Trial Is About
The clinical and demographic characteristics of patients undergoing transcatheter aortic valve implantation (TAVI) pose unique challenges for coronary computed tomography (CT) imaging, as this patient population is mainly composed of elderly, frail individuals with severe aortic stenosis, multiple comorbidities, high prevalence of heavily calcified coronary artery disease (CAD) and revascularized coronary arteries. Such vulnerable patients could benefit from a more precise assessment and characterization of their CAD with ultra-high resolution (UHR) photon-counting detector (PCD) CT that would potentially avoid the need for pre-implantation invasive coronary angiography (ICA). This international multicenter prospective registry study aims to investigate the feasibility and diagnostic accuracy of PCD-CT in the assessment of CAD in the high-risk population of patients undergoing TAVI, as compared to ICA.
CONDITIONS
Official Title
Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Clinically indicated transcatheter aortic valve implantation (TAVI)
- Clinically indicated CT and invasive coronary angiography
- No contraindications to CT angiography
- Ability to understand and sign the consent form
You will not qualify if you...
- Pregnancy or breastfeeding
- Chronic renal failure with eGFR less than 30 ml/m2
- Active oncological treatment
- Any condition that contraindicates TAVI and prior radiological investigation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 7 locations
1
Medical University of South Carolina
Charleston, South Carolina, United States, 29425
Actively Recruiting
2
Albert-Ludwigs-Universität Freiburg
Freiburg im Breisgau, Germany, 79098
Not Yet Recruiting
3
University Medical Center Mainz
Mainz, Germany, 55116
Actively Recruiting
4
Universitätsklinikum Tübingen
Tübingen, Germany, 2669
Not Yet Recruiting
5
Semmelweis University
Budapest, Hungary
Actively Recruiting
6
Maastricht University
Maastricht, Netherlands, 6211
Not Yet Recruiting
7
University Hospital of Zürich
Zurich, Switzerland, 8091
Not Yet Recruiting
Research Team
P
Pál Maurovich-Horvat, MD, PhD, DSc
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here