Actively Recruiting
Prospective Study for Endometrial Carcinoma and Hyperplasia in Childbearing-age Women
Led by Women's Hospital School Of Medicine Zhejiang University · Updated on 2024-05-16
75
Participants Needed
1
Research Sites
160 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this clinical trial is to evaluate the effect and adverse side effects of membrane-inhibiting formula plus oral progestins as fertility-preserving treatment in patients with early-stage endometrial cancer and endometrial hyperplasia research questions：When taken with oral progestins, does the drug membrane-inhibiting formula shorten the time required for complete endometrial remission? What medical problems do participants have when taking drug membrane-inhibiting formula plus oral progestins? Efficacy, side effects, recurrence, pregnancy, and time to obtain pregnancy in different molecular classifications of POLE-mutated, mismatch repair-deficient(MMRd), p53 wild type(p53wt), and p53-abnormal(p53abn). Participants will: Take drug membrane-inhibiting formula plus oral progestins every day Visit the clinic once every 3 months for checkups, tests, and hysteroscopy Keep a diary of examination results and pathology
CONDITIONS
Official Title
Prospective Study for Endometrial Carcinoma and Hyperplasia in Childbearing-age Women
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Aged 18 to 45 years with a strong desire to preserve fertility
- Pathologically confirmed primary grade 1 or grade 2 endometrioid endometrial carcinoma or endometrial hyperplasia
- No signs of suspicious myometrial invasion by enhanced MRI
- No signs of suspicious extrauterine metastasis by enhanced CT and lung CT scan
You will not qualify if you...
- Contraindication for pregnancy
- No fertility requirement
- Presence of myometrial invasion or extrauterine metastasis
- Pathologically diagnosed with primary grade 3 endometrioid endometrial carcinoma or non-endometrioid endometrial carcinoma
- Any disease or symptom that may affect study participation or result interpretation
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Women's Hospital School of Medicine Zhejiang University
Hangzhou, Zhejiang, China, 321006
Actively Recruiting
Research Team
Y
Yang Li, Doctor
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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