Study of a New Laparoscopic Surgery for Upper Stomach and Esophagogastric Junction Adenocarcinoma Evaluating Safety and Short-Term Quality of Life After Surgery

What this Trial Is About

Researchers are evaluating a new surgical technique called totally laparoscopic proximal gastrectomy with esophagogastrostomy by fissure technique to treat primary adenocarcinoma located in the upper third of the stomach or gastroesophageal junction Siewert II or III. This single-center, open-label Phase IbII study focuses on assessing perioperative safety and postoperative outcomes, including quality of life, in patients with this type of gastric cancer. Participants will undergo the laparoscopic surgery that preserves two-thirds of the distal stomach and includes D1 to D2 lymph node dissection. The anastomosis is performed using the fissure technique, with specific plans to manage any anastomotic rupture. The study will observe patients through the surgery and at least three months following, with clinical data collected to evaluate safety and recovery. During the study, researchers will monitor surgery duration, blood loss, and postoperative recovery within 30 days, as well as pathological staging. At three months, endoscopy will assess reflux esophagitis and anastomotic stenosis. Quality of life will be measured using EORTC QLQ-C30 and QLQ-STO22 questionnaires. Participants will be closely followed to understand safety and short-term quality of life impacts after surgery.

A Prospective Study on Esophagogastrostomy by an Innovative Surgical Technique