Actively Recruiting
A Prospective Study to Evaluate Clinical Outcomes in Anti-LGI1 Encephalitis
Led by Shen Chun-Hong · Updated on 2025-08-27
60
Participants Needed
1
Research Sites
554 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis has been increasingly identified as the second most common type of autoimmune encephalitis after anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis. It presents with acute or subacute onset of epileptic seizures, anterograde amnesia, behavior disturbances, sleep disorders and hyponatremia. In most patients with anti-LGI1 encephalitis, immunotherapy is successful in treating the encephalitis. However, relapses, chronic epilepsy, cognitive declines and psychiatric problems have been reported in some cases. So far, prospective studies to evaluate its clinical outcomes still remain limited. In this project, the investigators will use clinical features and advanced paraclinical examinations to prospectively investigate the clinical outcomes and the associated factors in patients with anti-LGI1 encephalitis.
CONDITIONS
Official Title
A Prospective Study to Evaluate Clinical Outcomes in Anti-LGI1 Encephalitis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Meet the 2016 consensus diagnostic criteria for anti-LGI1 encephalitis
- Newly diagnosed and currently in the acute stage before study enrollment
- Signed informed consent form
You will not qualify if you...
- History of epilepsy, stroke, brain trauma, or other nervous system diseases before encephalitis onset
- Presence of other antibodies such as anti-contactin-associated protein 2 (CASPR2) antibody
- Lost to follow-up
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
2nd Affiliated Hospital, School of Medicine, Zhejiang University, China
Hangzhou, Zhejiang, China
Actively Recruiting
Research Team
M
Mei-Ping Ding
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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