Observational Study of Lymphatic Changes Using ICG Lymphography Before and After Radiotherapy in Women with Breast Cancer

What this Trial Is About

Researchers are studying how the lymphatic system changes before and after radiotherapy in female patients with stage I-III breast cancer. This observational study aims to understand early lymphatic changes that could lead to breast-cancer-related lymphedema BCRL and to help identify patients who might benefit from early preventive rehabilitation. The study is led by Inah Kim and focuses on measuring lymphatic flow and vessel function using a special imaging technique called indocyanine green ICG lymphography. Participants will undergo ICG lymphography before starting radiotherapy and again within 4 to 6 weeks after completing the treatment. Some participants may also have follow-up imaging at 3, 6, or 12 months to monitor long-term changes. The ICG test involves a small injection of dye under the skin, followed by near-infrared imaging to visualize lymphatic flow. All participants will receive radiotherapy as part of their standard breast cancer care, with no experimental treatments or comparison groups involved. During the study, participants will have their lymphatic function assessed using ICG lymphography at multiple time points. Researchers will also measure arm circumference and volume and collect patient-reported information about arm discomfort or swelling. These data will help identify early signs of radiation-induced lymphatic problems. Participants will continue their usual medical and rehabilitation care throughout the study. The total participation duration may extend up to 12 months for those who undergo long-term follow-up imaging.

Prospective Study on ICG Lymphoscintigraphy Changes Before and After Radiotherapy in Breast Cancer Patients