Actively Recruiting
Prospective Study of Immune Alterations in Operable Breast and Ovarian Carcinoma
Led by Centre Leon Berard · Updated on 2026-04-27
160
Participants Needed
1
Research Sites
521 weeks
Total Duration
On this page
Sponsors
C
Centre Leon Berard
Lead Sponsor
C
Cancer Research Center of Lyon
Collaborating Sponsor
AI-Summary
What this Trial Is About
GYNECO-IMM\&Co is a prospective clinical and biological cohort ; this study aims to identify immune surveillance and escape mechanisms and also predictive biomarkers for survival patients who suffer from ovarian and breast carcinoma.
CONDITIONS
Official Title
Prospective Study of Immune Alterations in Operable Breast and Ovarian Carcinoma
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Female patients aged 18 years or older at the time of informed consent.
- Patients scheduled for primary tumor surgery for either high grade serous ovarian carcinoma, breast carcinoma grade II or III larger than 3 cm, or extensive breast carcinoma in situ with invasive nodule eligible for mastectomy.
- Patients who understand and sign the written informed consent and agree to follow study procedures.
- Patients must have medical insurance coverage.
You will not qualify if you...
- Patients under legal guardianship or trusteeship.
- Patients with cancer linked to constitutional BRCA1/2 mutations.
- Patients previously treated with immunomodulators such as PD1/PDL1 or CTLA4 inhibitors.
- Patients receiving systemic immunosuppressive treatments or immunostimulants within 2 weeks before inclusion, except certain low-dose corticosteroids and topical forms.
- Patients with known autoimmune diseases including myasthenia gravis, myositis, autoimmune hepatitis, lupus, rheumatoid arthritis, inflammatory bowel disease, vascular thrombosis with antiphospholipid syndrome, Wegener syndrome, Sjögren syndrome, Guillain-Barré syndrome, multiple sclerosis, vasculitis, glomerulonephritis, hepatitis B or C, or HIV infection.
- Patients with other active tumors unless approved by the sponsor and considered not to interfere with study outcomes.
- Pregnant or breastfeeding women.
AI-Screening
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Trial Site Locations
Total: 1 location
1
Centre Léon Bérard
Lyon, France, France, 69008
Actively Recruiting
Research Team
N
Nicolas Chopin
CONTACT
C
Christophe Caux
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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