Actively Recruiting
A Prospective Study of a Modified Lumbar Puncture (LP) Procedure That Reduces Post-Lumbar Puncture Headaches (PLPH) in Patients
Led by The University of Texas Health Science Center, Houston · Updated on 2025-06-13
100
Participants Needed
1
Research Sites
125 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The purpose of this study is to o determine whether the modified LP procedure reduces the incidence of PLPH to 5% or lower, to determine whether the modified LP procedure reduces the frequency of epidural blood patch (EBP) usage to 10% or lower of the PLPH population and to identify factors that may contribute to or reduce incidence of PLPH
CONDITIONS
Official Title
A Prospective Study of a Modified Lumbar Puncture (LP) Procedure That Reduces Post-Lumbar Puncture Headaches (PLPH) in Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Able to sign informed consent
- Willing to comply with all study procedures and available for the study duration
- Receiving lumbar puncture per standard of care for diagnostic or therapeutic purposes
- Karnofsky Performance Scale score of 60 or higher
You will not qualify if you...
- History of chronic headaches (15 or more days per month) or acute headaches
- Recent neurosurgical device implants such as ventriculoperitoneal shunt
- More than one dural puncture during the same lumbar puncture procedure
- Chronic coagulopathy with elevated prothrombin time, partial thromboplastin time, or INR
- On active anticoagulant or antiplatelet therapy unless stopped per standard of care before lumbar puncture
- Suspected raised intracranial pressure by clinical or imaging assessment
- Severe spinal column deformities such as scoliosis (disc diseases are not excluded)
- Lumbar puncture complications requiring needle type or size change
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
The University of Texas Health Science Center at Houston
Houston, Texas, United States, 77030
Actively Recruiting
Research Team
J
Jay-Jiguang Zhu, MD,PhD
CONTACT
A
Austin Lu
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here