Actively Recruiting
Effects of Vasopressors on Brain Oxygen Levels During General Anesthesia in Abdominal Surgery
Led by Dalian Municipal Central Hospital · Updated on 2024-11-06
180
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of three vasopressors—norepinephrine, phenylephrine, and ephedrine—on brain oxygen levels during general anesthesia for abdominal surgery. This randomized, double-blind trial aims to understand how these drugs influence cerebral oxygen saturation and heart function in patients undergoing surgery with either propofol or sevoflurane anesthesia. Participants receive one of six treatment groups, combining one of the three vasopressors with either propofol or sevoflurane anesthesia. When a patient’s mean arterial blood pressure drops by 20% after anesthesia induction and intubation, they are given a dose of the assigned vasopressor to study its effect on blood pressure and cerebral oxygenation. Doses are tailored by weight and administered intravenously with close monitoring. During the study, patients’ brain oxygen levels and various heart and blood pressure measures are continuously recorded using specialized monitoring devices. Measurements are taken at key times, such as after entering the operating room, during blood pressure drops, and after vasopressor administration. The study tracks changes in heart rate, stroke volume, cardiac output, and vascular resistance to better understand each drug's impact on circulation and brain oxygen supply.
CONDITIONS
Brief Title
A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia
Who Can Participate
Eligibility Criteria
You may qualify if you...
- ASA physical status I to III, aged 18 to 80 years
- Scheduled for elective abdominal surgery
- Signed informed consent to participate
You will not qualify if you...
- ASA physical status IV or higher
- Unstable blood pressure or blood flow before surgery
- Allergy to ephedrine, phenylephrine, or norepinephrine
- Mean arterial pressure decrease less than 20%
- Severe cardiovascular disorders
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Duration of surgery and anesthesia
Participants receive general anesthesia for elective abdominal surgery and are randomized to receive one of three vasopressors (ephedrine, phenylephrine, or norepinephrine) during anesthesia when blood pressure decreases by 20% from baseline. Cerebral oxygenation and cardiovascular parameters are monitored continuously during surgery.
1 visit (in-person, during surgery)
Trial Site Locations
Total: 1 location
1
Dalian Municipal Central Hospital
Dalian, Liaoning, China, 116033
Actively Recruiting
Research Team
L
Liping Han, MD, MSc
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
6
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