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Study on Effects of Ephedrine, Phenylephrine, and Norepinephrine on Brain Oxygen Levels During Abdominal Surgery Under General Anesthesia
Led by Dalian Municipal Central Hospital · Updated on 2024-11-06
180
Participants Needed
1
Research Sites
N/A
Total Duration
AI-Summary
What this Trial Is About
Researchers are evaluating the effects of three vasopressorsnorepinephrine, phenylephrine, and ephedrineon brain oxygen levels during general anesthesia for abdominal surgery. This randomized, double-blind trial aims to understand how these drugs influence cerebral oxygen saturation and heart function in patients undergoing surgery with either propofol or sevoflurane anesthesia. Participants receive one of six treatment groups, combining one of the three vasopressors with either propofol or sevoflurane anesthesia. When a patients mean arterial blood pressure drops by 20% after anesthesia induction and intubation, they are given a dose of the assigned vasopressor to study its effect on blood pressure and cerebral oxygenation. Doses are tailored by weight and administered intravenously with close monitoring. During the study, patients brain oxygen levels and various heart and blood pressure measures are continuously recorded using specialized monitoring devices. Measurements are taken at key times, such as after entering the operating room, during blood pressure drops, and after vasopressor administration. The study tracks changes in heart rate, stroke volume, cardiac output, and vascular resistance to better understand each drugs impact on circulation and brain oxygen supply.
CONDITIONS
Brief Title
A Prospective Study of Vasopressor on Cerebral Oxygenation During General Anesthesia
Research Team
L
Liping Han, MD, MSc
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