Actively Recruiting
Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression
Led by Case Comprehensive Cancer Center · Updated on 2026-05-07
10
Participants Needed
1
Research Sites
138 weeks
Total Duration
On this page
Sponsors
C
Case Comprehensive Cancer Center
Lead Sponsor
B
Burkhardt Brain Tumor and Neuro-Oncology Center
Collaborating Sponsor
AI-Summary
What this Trial Is About
The purpose of this study is to test the safety and feasibility of recording brain activity within and around high-grade glioma tumors at the time of surgery. A small biopsy will be taken at the sites of the recordings.
CONDITIONS
Official Title
Prospective Surgical Study on the Pattern of Electrical Activity in High Grade Glioma as a Predictor of Progression
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Participants with MRI appearance of high-grade glioma (WHO Grade 3 or 4) or history of confirmed high-grade glioma undergoing tumor resection
- Age 18 years or older
- Volumetric MRI within 1 month prior to surgery
- Karnofsky performance status of 60 or higher
- Written informed consent provided by participant or legal representative
- Appropriate neurosurgical candidate with lab values within 1 month prior to surgery:
- Absolute neutrophil count ≥ 1500/µL
- Platelets ≥ 100,000/µL
- INR or PT and aPTT ≤ 1.5 times upper limit of normal unless on therapeutic anticoagulants
- Negative urine or serum pregnancy test (if applicable)
You will not qualify if you...
- Severe co-morbidities increasing surgical risk as determined by physician
- Major medical illnesses or psychiatric impairments preventing protocol therapy
- Pregnancy
- Coagulopathy or platelet dysfunction increasing bleeding risk
- Tumor location requiring electrode placement or biopsy in critical brain regions (motor, sensory, speech, vision centers, thalamus, basal ganglia, cerebellum, brain stem) as determined by neurosurgeon
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center
Cleveland, Ohio, United States, 44195
Actively Recruiting
Research Team
J
Jennifer Yu, MD, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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