Actively Recruiting
Prospective Validation of a Pharmacological Biomarker for Low-Dose Rituximab in Rheumatoid Arthritis
Led by University Hospital, Tours · Updated on 2026-04-30
30
Participants Needed
1
Research Sites
131 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Evaluation of the prediction of clinical response to rituximab at a dose of 1000 mg once using a pharmacological model including several pharmacokinetic and pharmacodynamic parameters.
CONDITIONS
Official Title
Prospective Validation of a Pharmacological Biomarker for Low-Dose Rituximab in Rheumatoid Arthritis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 2 18 years
- Diagnosis of rheumatoid arthritis meeting ACR/EULAR 2010 criteria
- Candidates for a low dose rituximab regimen: currently on standard dose rituximab with good clinical response
- Stable dose of co-prescribed csDMARDs (Methotrexate, Leflunomide, Salazopyrine, Plaquenil) for at least 3 months
- Stable corticosteroid dose 2 10 mg/day for at least 3 months if co-prescribed
You will not qualify if you...
- Use of other targeted disease-modifying therapies
- Diagnosis of Sj�f6gren's syndrome or other associated inflammatory rheumatism
- Fibromyalgia or other conditions affecting disease activity assessment
- Any active hematological disease affecting lymphocytes (e.g., chronic lymphocytic leukemia, Hodgkin's lymphoma, non-Hodgkin's lymphoma, lymphoplasmacytic lymphoma, T lymphoma)
- Opposition to data processing
- Persons covered by articles L. 1121-5 to L. 1121-8 and L. 1122-1-2 of the Public Health Code (e.g., minors, protected adults) are not eligible
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University hospital
Tours, France, 37044
Actively Recruiting
Research Team
S
Simon BRUNET
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
Not the Right Trial for You?
Explore thousands of other clinical trials that might be a better match.
Sign up to get personalized trial recommendations delivered to your inbox.
Already have an account? Log in here