Actively Recruiting
The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)
Led by VA Office of Research and Development · Updated on 2026-01-13
5000
Participants Needed
1
Research Sites
347 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Prostate cancer is the most common non-skin cancer among Veterans and the second leading cause of male cancer death. Current methods of screening men for prostate cancer are inaccurate and cannot identify which men do not have prostate cancer or have low-grade cases that will not cause harm and which men have significant prostate cancer needing treatment. False-positive screening tests can result in unnecessary prostate biopsies for men who do not need them. However, new genetic testing might help identify which men are at highest risk for prostate cancer. This study will examine whether a genetic test helps identify men at risk for significant prostate cancer while helping men who are at low risk for prostate cancer avoid unnecessary biopsies. If this genetic test proves beneficial, it will improve the way that healthcare providers screen male Veterans for prostate cancer.
CONDITIONS
Official Title
The Prostate Cancer, Genetic Risk, and Equitable Screening Study (ProGRESS)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 55 and 69 years
- Receiving regular care at the VA
- Veteran status
You will not qualify if you...
- Personal history of prostate cancer
- Prior prostate biopsy, prostatectomy, or prostate MRI
- Known carrier of a rare genetic variant linked to cancer syndrome
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, United States, 02130-4817
Actively Recruiting
Research Team
C
Charles A Brunette, PhD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
SCREENING
Number of Arms
2
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