Actively Recruiting
Prostate Cancer Genetic Risk Evaluation and Screening Study
Led by Massachusetts General Hospital · Updated on 2024-10-09
400
Participants Needed
1
Research Sites
1085 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This study aims to define the natural history of men at high genetic risk for prostate cancer on the basis of specific germline genetic mutations, family history, or Black/African ancestry and evaluate the utility of prostate MRI as a screening tool. The hypothesis is that this targeted population of men are at elevated risk of developing prostate cancer compared to the general population, and enhanced screening with MRI will enable early detection and diagnosis of potentially aggressive prostate cancer, characterization of the penetrance of specific mutations, and potentially identify new genetic risk mutations.
CONDITIONS
Official Title
Prostate Cancer Genetic Risk Evaluation and Screening Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Men 35 to 74 years old
- No known diagnosis of prostate cancer
- Life expectancy greater than 10 years
- Meet one of the following: documented pathogenic germline mutation in prostate cancer risk gene, strong family history with negative genetic testing, or self-identify as Black American or Black Caribbean with both parents and all four grandparents of Black/African ancestry
You will not qualify if you...
- Prior diagnosis or treatment of prostate cancer
- Inability to undergo prostate MRI
- Inability to receive MRI contrast agent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114
Actively Recruiting
Research Team
O
Olympia Price
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
3
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