Actively Recruiting
Prostate Cancer Postoperative Stereotactic Body Radiotherapy With Adaptive Technology for Minimizing Toxicity
Led by Jonsson Comprehensive Cancer Center · Updated on 2025-07-24
200
Participants Needed
1
Research Sites
576 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Single-arm, prospective registry study assessing changes in acute patient-reported urinary (GU) and gastrointestinal (GI) quality of life at the 24-month post-treatment time point following magnetic resonance imaging (MRI)-guided or computed tomography (CT)-guided stereotactic body radiotherapy (SBRT) delivered to the prostate bed +/- pelvic lymph nodes. The decision to offer an adaptive treatment will be at the clinician's discretion.
CONDITIONS
Official Title
Prostate Cancer Postoperative Stereotactic Body Radiotherapy With Adaptive Technology for Minimizing Toxicity
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologically confirmed localized adenocarcinoma of the prostate treated with radical prostatectomy
- Presence of at least one: adverse pathological features at prostatectomy, rising prostate-specific antigen on two or more tests exceeding 0.03 ng/mL, intermediate- or high-risk genomic classifier score, or prostate cancer in one or more lymph nodes at prostatectomy
- CT scan and MRI of the pelvis within 120 days before enrollment (exceptions allowed for certain conditions)
- Bone scan or advanced nuclear imaging within 120 days before enrollment if prostate-specific antigen is above 1.0 ng/mL
- Age 18 years or older
- Karnofsky Performance Status of 70 or higher and/or ECOG performance status less than 2
- Ability to understand and willingness to sign informed consent
You will not qualify if you...
- Evidence of distant metastases (lymphadenopathy below the renal arteries may be considered local-regional)
- Diagnosis of neuroendocrine or small cell carcinoma of the prostate
- Prior pelvic radiotherapy
- History of Crohn's Disease, Ulcerative Colitis, or Ataxia Telangiectasia
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University of California at Los Angeles
Los Angeles, California, United States, 90095
Actively Recruiting
Research Team
C
CHRISTY PALODICHUK
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
1
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