Actively Recruiting
The PROTECT Trial: PROpofol Titration to Enhance haemodynamiC sTability
Led by University Hospital, Basel, Switzerland · Updated on 2025-09-19
320
Participants Needed
4
Research Sites
104 weeks
Total Duration
On this page
Sponsors
U
University Hospital, Basel, Switzerland
Lead Sponsor
U
University of Basel
Collaborating Sponsor
AI-Summary
What this Trial Is About
The aim of this multicentre, single-blinded, expertise-based randomised controlled trial is evaluate whether slowly increasing the dose of the anaesthetic drug propofol based on a patient's needs leads to more stable blood pressure compared to giving a standard starting dose in patients aged 55 and older undergoing non-cardiac surgery.
CONDITIONS
Official Title
The PROTECT Trial: PROpofol Titration to Enhance haemodynamiC sTability
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 55 years old or older
- Scheduled for planned non-cardiac surgery under general anaesthesia with intubation including ear, nose and throat, gynaecological, maxillofacial, orthopedic, plastic and reconstructive, spine, urologic, vascular, and visceral surgeries
- Use of propofol Target-Controlled Infusion (TCI) with the Schnider model and remifentanil TCI with the Minto model for anaesthesia
- American Society of Anesthesiologists Physical Status Classification I-IV
- Body mass index (BMI) of 18.5 to less than 35 kg/m2
- Signed written informed consent
You will not qualify if you...
- Awake tracheal intubation or rapid sequence induction
- Combined general and regional anaesthesia procedures
- Opioid-free anaesthesia or opioid-sparing modifications using lidocaine, magnesium, ketamine, clonidine, or dexmedetomidine
- Surgery performed in prone position within the first 30 minutes
- Known difficult airway
- Daily alcohol consumption over one unit or more than seven units per week
- Regular recreational drug abuse
- Chronic use of benzodiazepines or opioids
- Allergy to propofol
- Known brain pathologies including seizure disorders, stroke within past 9 months, or dementia
- History of awareness during anaesthesia
- Inability to follow procedures or insufficient knowledge of German language
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 4 locations
1
Kantonsspital Baden
Baden, Switzerland, 5404
Not Yet Recruiting
2
University Hospital Basel
Basel, Switzerland, 4031
Actively Recruiting
3
Cantonal Hospital Graubünden
Chur, Switzerland, 7000
Not Yet Recruiting
4
Kantonsspital Olten, soH
Olten, Switzerland, 4600
Not Yet Recruiting
Research Team
M
Martin Lohri, Dr. med.
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
OTHER
Number of Arms
2
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