Actively Recruiting
Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training
Led by McGill University · Updated on 2026-03-03
126
Participants Needed
2
Research Sites
260 weeks
Total Duration
On this page
Sponsors
M
McGill University
Lead Sponsor
J
Jewish Rehabilitation Hospital
Collaborating Sponsor
AI-Summary
What this Trial Is About
The rates of cognitive decline and dementia after stroke are disproportionately high. Strategies that can protect the brain early after the stroke event could reduce the future risk of cognitive decline and dementia in these patients. Although physical exercise is usually recommended after stroke, there is very little information about the protective effect of exercise implemented in early stages of recovery as a potential protective measure against cognitive decline and dementia risk in these patients. This study will investigate the effect of a multimodal exercise intervention implemented early after the stroke event on cognition and on a selected group of markers that can predict cognitive decline and dementia risk.
CONDITIONS
Official Title
Protecting the Brain From Post-Stroke Cognitive Impairment and Dementia With Multimodal Exercise Training
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Have had a first-ever ischemic or hemorrhagic stroke confirmed by MRI or CT within 0 to 6 months before joining the study
- Able to walk independently at least 10 meters, with or without assistive devices
- Capable of following instructions
You will not qualify if you...
- Diagnosed with dementia
- Have absolute contraindications to exercise or MRI scanning
- Have significant disability with a modified Rankin score greater than 3
- Have severe untreated depression with a Beck Depression Inventory II score over 28
- Currently engaged in a structured exercise training program outside regular hospital rehabilitation since the stroke
- Have co-morbidities preventing exercise, pain worsened by exercise, or communication or behavioral issues limiting safe participation
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
McMaster University
Hamilton, Ontario, Canada, L8S 1C7
Active, Not Recruiting
2
Jewish Rehabilitation Hospital
Laval, Quebec, Canada
Actively Recruiting
Research Team
M
Marc Roig
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
DOUBLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
PREVENTION
Number of Arms
2
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