Actively Recruiting
Protective Effect of Sivelestat Against Negative Pulmonary Function and Organ Dysfunction After Cardiovascular Surgery (PANDA VI)
Led by Nanjing Medical University · Updated on 2024-11-22
500
Participants Needed
2
Research Sites
78 weeks
Total Duration
On this page
Sponsors
N
Nanjing Medical University
Lead Sponsor
T
The First Affiliated Hospital with Nanjing Medical University
Collaborating Sponsor
AI-Summary
What this Trial Is About
Systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS) are the major causes of death in patients with cardiovascular diseases. Therefore, the prevention of SIRS and MODS is of great clinical value, and immunomodulatory therapy with sivelestat may be beneficial. This study was designed to test the hypothesis that the administration of sivelestat during the acute phase of cardiovascular diseases will result in a reduced incidence of SIRS and MODS.
CONDITIONS
Official Title
Protective Effect of Sivelestat Against Negative Pulmonary Function and Organ Dysfunction After Cardiovascular Surgery (PANDA VI)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patients meet 2010 ACC/AHA guidelines for thoracic aortic disease diagnosis and treatment within two weeks of onset
- Patients with type A acute aortic syndrome confirmed clinically and by imaging, planned for emergency surgery
- Age between 18 and 90 years
- Agree to participate and sign informed consent
You will not qualify if you...
- Allergy to sivelestat sodium
- Pregnant or breastfeeding women
- Patients with mental illness or drug and alcohol dependence
- Refusal to participate or to sign informed consent
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 2 locations
1
Beijing Anzhen Hospital
Beijing, China
Actively Recruiting
2
The First Affiliated Hospital of Nanjing Medical University and Jiang ye-fan
Nanjing, China
Actively Recruiting
Research Team
H
Hong Liu, MD
CONTACT
S
Sheng Zhao, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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