Actively Recruiting
Protein Supplementation in Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis
Led by University Hospital, Basel, Switzerland · Updated on 2025-07-10
70
Participants Needed
1
Research Sites
102 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The goal of this study is to assess the impact of protein supplementation on hyponatremia caused by the syndrome of inappropriate antidiuresis during hospitalization.
CONDITIONS
Official Title
Protein Supplementation in Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult patients with confirmed syndrome of inappropriate antidiuresis (SIAD) during hospital stay or screening
- Plasma sodium concentration below 135 mmol/L
- Plasma osmolality below 300 mOsm/kg
- Urine osmolality above 100 mOsm/kg
- Urine sodium concentration above 30 mmol/L
- Clinical euvolemia with no signs of low or high blood volume
You will not qualify if you...
- Allergies to lactose, milk protein, soy, nuts, or protein supplement components
- Inborn metabolic disorders affecting carbohydrate, lipid, or protein metabolism
- Severe symptomatic hyponatremia requiring 3% sodium chloride or intensive care
- Treatment within past 5 days with SGLT2 inhibitors, vaptans, or oral urea
- Uncontrolled severe hypothyroidism or adrenal insufficiency
- Kidney function with eGFR below 45 mL/min/1.73 m² or end-stage renal disease requiring dialysis
- Severe liver impairment or advanced liver disease with encephalopathy, cirrhosis Child C, or decompensation
- Pregnancy, breastfeeding, or plans to become pregnant during study
- Receiving end-of-life care
- Inability to consent or follow procedures due to language, psychological issues, dementia, etc.
- Current treatment with thiazide diuretics unless stopped at least 48 hours before inclusion
- Post-randomization exclusion: type 1 diabetes or uncontrolled type 2 diabetes with HbA1c over 8.0%
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
University Hospital Basel
Basel, Switzerland, 4031
Actively Recruiting
Research Team
M
Mirjam Christ-Crain, Prof. MD
CONTACT
C
Cemile Bathelt
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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