Actively Recruiting

Phase Not Applicable
FEMALE
NCT06912490

Proteomic Analysis of Amniotic Fluid to Predict Postnatal Renal Function in Fetuses With Renal and Urinary Tract Malformations

Led by University Hospital, Toulouse · Updated on 2026-05-04

78

Participants Needed

1

Research Sites

230 weeks

Total Duration

On this page

AI-Summary

What this Trial Is About

The aim of this project is to validate a previously established amniotic fluid 98 peptide signature predictive of post-natal outcome in fetuses with congenital anomalies of the kidney and the urinary tract (CAKUT) in a "real" clinical context. It includes the feasibility of collecting, transporting and analyzing the amniotic fluid peptidome from clinical centers all over France and of providing the result in a clinically accepted time-frame. Therefore, this multicenter study will not only allow to determine the added value of such new prenatal test but also to ensure the feasibility of its introduction in the management of CAKUT pregnancies.

CONDITIONS

Official Title

Proteomic Analysis of Amniotic Fluid to Predict Postnatal Renal Function in Fetuses With Renal and Urinary Tract Malformations

Who Can Participate

FEMALE

Eligibility Criteria

Eligible

You may qualify if you...

  • All fetuses with bilateral renal development anomalies with structural changes in the parenchyma, with or without associated urinary tract anomalies
  • Signed informed consent of the mother
  • Non-opposition of the father
Not Eligible

You will not qualify if you...

  • Unilateral abnormality of renal development
  • Any pregnancy for which amniocentesis may represent a risk for the fetus or the mother
  • Twin pregnancies
  • Pregnant woman protected by law (guardianship, curatorship)

AI-Screening

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Trial Site Locations

Total: 1 location

1

Children Hospital

Toulouse, France, 31059

Actively Recruiting

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Research Team

T

Thomas SIMON

CONTACT

N

Nadège Algans

CONTACT

How is the study designed?

Study Type

INTERVENTIONAL

Masking

NONE

Allocation

NA

Model

SINGLE_GROUP

Primary Purpose

DIAGNOSTIC

Number of Arms

1

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