Targeted Proteomic Analysis in the Plasma of Children With Diabetes Type 1 and Its Association With Peripheral Diabetic Neuropathy

What this Trial Is About

Researchers are studying children of Greek origin aged 5 to 10 years with type 1 diabetes (DT1) to explore how proteins in their blood relate to early signs of diabetic peripheral neuropathy. This condition is a common complication in adults with DT1 but is rare in children. The study aims to identify specific protein markers in plasma alongside nerve function tests to detect neuropathy before symptoms appear. Participants include children with confirmed DT1 under insulin treatment and a healthy control group. Blood samples are taken from both groups for detailed protein analysis. Additionally, children with DT1 undergo an electrophysiological nerve conduction study to assess nerve function. The study runs from 2018 to 2020, focusing on specific plasma proteins and nerve testing results. During the study, children will have blood drawn for protein analysis and undergo nerve conduction tests. Researchers will monitor levels of various proteins such as sorbitol, fructose, and several fatty acids in plasma. The goal is to correlate these findings with nerve function to detect early neuropathy. The study involves informed consent from parents or guardians and monitors glycemic control and health status throughout participation.

Proteomic Analysis in Paediatric Diabetes Type 1 (PAPD)