Actively Recruiting
Proteomic Analysis in Paediatric Diabetes Type 1 (PAPD)
Led by Aristotle University Of Thessaloniki · Updated on 2024-07-31
50
Participants Needed
1
Research Sites
321 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The aim of the present study is to investigate a targeted proteomic analysis in plasma of children - of Greek origin- with type 1 diabetes (DT1) and its correlation with the electrophysiological findings that accompany diabetic peripheral neuropathy. Diabetic neuropathy is the most frequent chronic complication in adults with DT1 and rarely appears in childhood. Nevertheless, cases of acute mononeuritis have been described at the time of diagnosis of DT1. According to recent reports several biomarkers, including proteomic analysis, have been proposed for the early detection of peripheral neuropathy in children and young adults with T1DM. In the present study the researchers will attempt to investigate the role of biomarkers with targeted proteomic analysis in the plasma of children with DT1 in combination with an electrophysiological study, which includes a nerve conduction study, to detect early diabetic peripheral neuropathy, before the appearance of clinical manifestations.
CONDITIONS
Official Title
Proteomic Analysis in Paediatric Diabetes Type 1 (PAPD)
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Children with confirmed type 1 diabetes under insulin therapy
- Age between 5 and 10 years
- Good blood sugar control with HbA1c ≤ 7.0%
- Prepubertal patients
- No other diseases present
- Signed informed consent by parent or guardian
You will not qualify if you...
- Presence of any organic cause for neuropathy
- Having other chronic diseases
- Poor blood sugar control
- Use of medications that affect study outcomes
AI-Screening
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Trial Site Locations
Total: 1 location
1
Unit of Pediatric Endocrinology, Diabetes and Metabolism-2nd Department of Pediatrics, School of Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki
Thessaloniki, Greece, 54621
Actively Recruiting
Research Team
A
Assimina Galli-Tsinopoulou, MD,PhD
CONTACT
E
Eleni Litou, MD
CONTACT
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
2
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