Actively Recruiting
Proteomic Biomarker Identification in AMD, Diabetic Retinopathy and Retinal Detachment
Led by Fondazione G.B. Bietti, IRCCS · Updated on 2026-03-30
260
Participants Needed
1
Research Sites
153 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
This prospective interventional translational study aims to identify and validate protein biomarkers associated with major ophthalmological diseases, including age-related macular degeneration (AMD), diabetic retinopathy (DR), and retinal detachment (RD). A total of approximately 260 participants (cases and controls) will be enrolled at a single center. Biological samples, including peripheral blood, tears, aqueous humor, vitreous humor, and subretinal fluid, will be collected during routine clinical and surgical procedures. Advanced clinical proteomics approaches will be applied to characterize molecular signatures associated with disease onset, progression, and response to treatment. The study seeks to improve the understanding of disease pathophysiology and support the development of novel diagnostic and prognostic biomarkers in ophthalmology.
CONDITIONS
Official Title
Proteomic Biomarker Identification in AMD, Diabetic Retinopathy and Retinal Detachment
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age 18 years or older
- Ability to understand study procedures and provide written informed consent
- Willingness and ability to comply with study procedures and visits
- Patients with intermediate or advanced age-related macular degeneration (including geographic atrophy or neovascular AMD)
- Patients with non-proliferative or proliferative diabetic retinopathy, with or without diabetic macular edema
- Patients undergoing surgery for primary or recurrent retinal detachment
- Patients scheduled for cataract surgery without retinal diseases
- Outpatients without documented retinal diseases
- For retinal detachment subgroup: patients undergoing macular surgery (e.g., macular pucker or macular hole) or cataract surgery with attached retina
You will not qualify if you...
- Age under 18 years
- Presence of infectious ocular diseases
- Alterations in the electrophoretic profile of gamma globulins
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
IRCCS Fondazione G.B.Bietti
Roma, Italy, Italy, 00184
Actively Recruiting
Research Team
M
Mariacristina Parravano, MD
CONTACT
T
Tommaso Rossi, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
DIAGNOSTIC
Number of Arms
1
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