Study to Identify and Validate Protein Biomarkers in Eye Diseases Including Age-Related Macular Degeneration, Diabetic Retinopathy, and Retinal Detachment

What this Trial Is About

Researchers are conducting a prospective interventional translational study to identify and validate protein biomarkers linked to major eye diseases such as age-related macular degeneration, diabetic retinopathy, and retinal detachment. The study aims to improve understanding of these diseases development and support new diagnostic and prognostic tools in ophthalmology. Approximately 260 participants, including patients with these eye conditions and control subjects without retinal disease, will be enrolled at a single center. Participants will have biological samples collected during routine clinical care, such as peripheral blood, tears, and ocular fluids like aqueous humor, vitreous humor, and subretinal fluid during surgeries. The study involves baseline visits with eye examinations and imaging, followed by additional sample collection during therapeutic procedures when applicable. Advanced proteomics techniques, including high-resolution mass spectrometry, will be used to analyze these samples in phases focusing on biomarker discovery and validation. Throughout the study, participants will undergo comprehensive eye exams, medical history reviews, and non-invasive imaging. Samples will be collected without adding risk beyond routine care. Researchers will examine molecular signatures related to disease onset and progression and assess protein biomarkers over up to 36 months. Data will be statistically analyzed, and all personal information will be protected according to data privacy regulations.

Proteomic Biomarker Identification in Age-Related Macular Degeneration, Diabetic Retinopathy and Retinal Detachment