Actively Recruiting
A Protocol Based-Furosemide Stress Test to Evaluate Renal Recovery During Continuous Renal Replacement Therapy
Led by Chiang Mai University · Updated on 2026-03-24
80
Participants Needed
1
Research Sites
260 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
Currently, continuous renal replacement therapy (CRRT) is the main modality for renal support in critically ill patients with hemodynamic instability. Most studies have investigated the timing of RRT initiation. However, prolonged CRRT demonstrated the association of many unexpected events, such as catheter-related complications, catheter-related blood stream infection, hypotension, hypothermia, tachycardia, and atrial fibrillation. Up to now, there is a lack of evidence regarding the timing of withholding CRRT. The furosemide stress test (FST) is a tool that is easy to use and has more availability. The investigators aimed to apply FST to evaluate renal recovery compared with standard treatment in critically ill patients undergoing CRRT.
CONDITIONS
Official Title
A Protocol Based-Furosemide Stress Test to Evaluate Renal Recovery During Continuous Renal Replacement Therapy
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adults 20 years of age or older
- Acute kidney injury stage 3 with urine output less than 400 mL per day
- Undergoing continuous renal replacement therapy in ICU for at least 48 hours (CRRT timing and method can be adjusted by clinician)
You will not qualify if you...
- Use of any inotropic drugs (norepinephrine, epinephrine, dopamine, dobutamine)
- Blood urea nitrogen (BUN) greater than 80 mg/dL
- Serum potassium less than 3.5 or greater than 5 mmol/L
- Blood pH less than 7.3
- Serum bicarbonate less than 15 mmol/L
- Urine volume less than 400 or greater than 2,100 mL per day
- Urine creatinine clearance at 6 hours greater than 20 mL/min
- History of chronic kidney disease stage 5 or estimated glomerular filtration rate less than 15 mL/min/1.73 m2
- Received renal replacement therapy within the past 14 days
- Kidney transplantation
- Obstructive causes of acute kidney injury
- Toxin or drug exposure requiring renal replacement therapy
- Allergy to furosemide
- Expected death within 24 hours
- Pregnancy
AI-Screening
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Trial Site Locations
Total: 1 location
1
Chiang Mai University
Chiang Mai, Thailand, 50200
Actively Recruiting
Research Team
P
Prit Kusirisin, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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