Epidemiology of continuous renal replacement therapy in Korea: Results from the National Health Insurance Service claims database from 2005 to 2016.
Sehoon Park, Soojin Lee, Hyung Ah Jo...
https://pubmed.ncbi.nlm.nih.gov/29971207Actively Recruiting
Phase 4
Age: 20Years +
All Genders
ID06229990
A Protocol Based-Furosemide Stress Test to Evaluate Renal Recovery During Continuous Renal Replacement Therapy (FST-STOP): A Randomized Controlled Trial
Led by Chiang Mai University · Updated on 2026-03-24
80
Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are evaluating the use of a furosemide stress test (FST) to help determine kidney recovery in critically ill patients with acute kidney injury (AKI) who are undergoing continuous renal replacement therapy (CRRT). This study aims to address the lack of evidence on the best timing to stop CRRT, as prolonged CRRT can lead to complications like infections, low blood pressure, and heart rhythm issues. The study is a randomized controlled trial sponsored by Chiang Mai University.
CONDITIONS
Brief Title
A Protocol Based-Furosemide Stress Test to Evaluate Renal Recovery During Continuous Renal Replacement Therapy
Who Can Participate
Age: 20Years +
All Genders
Eligibility Criteria
You may qualify if you...
- Adult 20 years of age or older
- Acute kidney injury stage 3 according to KDIGO classification with urine output less than 400 ml/day
- Initiated continuous renal replacement therapy in ICU for at least 48 hours (timing and modality can be adjusted by clinician)
You will not qualify if you...
- Use of any inotropic drugs such as norepinephrine, epinephrine, dopamine, or dobutamine
- Blood urea nitrogen (BUN) greater than 80 mg/dL
- Serum potassium less than 3.5 or greater than 5 mmol/L
- Arterial pH less than 7.3
- Serum bicarbonate less than 15 mmol/L
- Urine volume less than 400 or greater than 2,100 ml/day
- Urine creatinine clearance at 6 hours greater than 20 mL/min
- Previous chronic kidney disease stage 5 or estimated glomerular filtration rate less than 15 mL/min/1.73 m2
- Previous renal replacement therapy within 14 days
- History of kidney transplantation
- Obstructive cause of acute kidney injury
- Presence of toxins or drugs that require renal replacement therapy
- Allergy to furosemide
- Moribund state with expected death within 24 hours
- Pregnancy
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
1
2
3
Your Study Journey
Screening
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Treatment
Duration - Up to 5 days
Participants receive intravenous furosemide injections with dosage adjusted based on urine output to evaluate renal recovery during continuous renal replacement therapy.
1 baseline visit and daily visits during treatment
Follow-up
Duration - Up to 28 days
Participants are monitored for renal recovery, mortality, complications, and other health outcomes up to 28 days after treatment.
Weekly visits for up to 4 weeks
Trial Site Locations
Total: 1 location
1
Chiang Mai University
Chiang Mai, Thailand, 50200
Actively Recruiting
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Research Team
P
Prit Kusirisin, MD
How is the study designed?
Study Type
INTERVENTIONAL
Masking
QUADRUPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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Published Research Related To This Trial
Initiation Strategies for Renal-Replacement Therapy in the Intensive Care Unit.
Stéphane Gaudry, David Hajage, Fréderique Schortgen...
https://pubmed.ncbi.nlm.nih.gov/27181456Effect of Early vs Delayed Initiation of Renal Replacement Therapy on Mortality in Critically Ill Patients With Acute Kidney Injury: The ELAIN Randomized Clinical Trial.
Alexander Zarbock, John A Kellum, Christoph Schmidt...
https://pubmed.ncbi.nlm.nih.gov/27209269Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis.
Saber D Barbar, Raphaël Clere-Jehl, Abderrahmane Bourredjem...
https://pubmed.ncbi.nlm.nih.gov/30304656Timing of Initiation of Renal-Replacement Therapy in Acute Kidney Injury.
STARRT-AKI Investigators, Canadian Critical Care Trials Group, Australian and New Zealand Intensive Care Society Clinical Trials Group...
https://pubmed.ncbi.nlm.nih.gov/32668114Comparison of two delayed strategies for renal replacement therapy initiation for severe acute kidney injury (AKIKI 2): a multicentre, open-label, randomised, controlled trial.
Stéphane Gaudry, David Hajage, Laurent Martin-Lefevre...
https://pubmed.ncbi.nlm.nih.gov/33812488Incidence of Adverse Events during Continuous Renal Replacement Therapy.
Abbasali Akhoundi, Balwinder Singh, Myriam Vela...
https://pubmed.ncbi.nlm.nih.gov/26022612Development and standardization of a furosemide stress test to predict the severity of acute kidney injury.
Lakhmir S Chawla, Danielle L Davison, Ermira Brasha-Mitchell...
https://pubmed.ncbi.nlm.nih.gov/24053972Early versus standard initiation of renal replacement therapy in furosemide stress test non-responsive acute kidney injury patients (the FST trial).
Nuttha Lumlertgul, Sadudee Peerapornratana, Thananda Trakarnvanich...
https://pubmed.ncbi.nlm.nih.gov/29673370Determining sample size for progression criteria for pragmatic pilot RCTs: the hypothesis test strikes back!
M Lewis, K Bromley, C J Sutton...
https://pubmed.ncbi.nlm.nih.gov/33536076