Effect of Protocol-Based Antithrombotic Management on Surgery Outcomes in Patients Taking Chronic Antithrombotic Drugs

What this Trial Is About

Managing surgical patients who take antithrombotic medications is challenging because these drugs affect blood clotting, increasing bleeding risk, but stopping them may cause clot-related problems. This research evaluates whether following a protocol-based approach for managing antithrombotic therapy around the time of surgery can improve outcomes for patients who have been on long-term antithrombotic treatment. The study is interventional and pragmatic in design, aiming to assess the impact of such management on perioperative events. Participants are assigned to one of two groups one group receives perioperative antithrombotic management based on the latest expert consensus guidelines published in 2020, while the other group receives routine care as usual. Both approaches involve managing antithrombotic drugs before, during, and after surgery, specifically in patients undergoing intra-abdominal surgeries including general and urologic operations. During the study, researchers will monitor participants for up to 30 days after surgery to assess a combined outcome of major bleeding and serious cardiovascular or cerebrovascular events. They will also track other postoperative complications, length of hospital stay, total hospital expenses, and all-cause mortality within this period. Participants will have preoperative assessments and follow-up visits to gather this information and ensure safety throughout the study.

Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy