Actively Recruiting
Early Detection and Prevention of Health Complications in Premature Infants - Protocol-driven Nutrition
Led by Institute of Health Information and Statistics of the Czech Republic · Updated on 2026-01-23
400
Participants Needed
5
Research Sites
9 weeks
Total Duration
On this page
Sponsors
I
Institute of Health Information and Statistics of the Czech Republic
Lead Sponsor
G
General University Hospital, Prague
Collaborating Sponsor
AI-Summary
What this Trial Is About
This research aims to develop and test a standardized, protocol-driven nutritional approach for preterm infants in the Czech Republic. The goal is to improve early growth and reduce health complications related to prematurity by creating a national care methodology focused on individualized nutrition. This multicenter pilot project involves multiple healthcare facilities and is supported by national and European funding. The study involves personalized nutrition plans created by attending physicians using advanced clinical nutrition software. This software helps monitor infants' growth and nutrient intake precisely, adjusting plans based on regular weight, length, and head circumference measurements and weekly analysis of maternal or donor milk composition. The project promotes early enteral feeding to improve growth and reduce risks like bronchopulmonary dysplasia and retinopathy. Participants will be preterm infants admitted to neonatal care within 24 hours of birth and monitored until 36 weeks corrected gestational age. Researchers will track growth using z-scores for body weight, length, and head circumference compared to typical term infants. The study includes detailed data collection on nutrition and growth, with close clinical monitoring to assess safety and outcomes over the study period.
CONDITIONS
Brief Title
Protocol-driven Nutrition in Preterm Infants
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Infants born before 31+6 weeks gestation
- Signed consent for participation and data processing
- Admission to neonatal care in participating hospital within 24 hours after birth
You will not qualify if you...
- Presence of congenital malformations
- Fetal hydrops
- Intraventricular hemorrhage requiring drainage
- Necrotizing enterocolitis requiring surgical treatment
- Surgically treated hydrocephalus
- No signed consent for participation or data processing
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - Up to 24 hours after birth
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Up to 36 weeks corrected gestational age
Participants receive individualized nutritional management guided by advanced clinical nutrition software, with regular anthropometric assessments and weekly analysis of milk composition to optimize growth and reduce complications.
Regular assessments integrated within neonatal care
Trial Site Locations
Total: 5 locations
1
Brno University Hospital
Brno, Czech Republic, Czechia
Not Yet Recruiting
2
České Budějovice Hospital
České Budějovice, Czech Republic, Czechia
Actively Recruiting
3
University Hospital Olomouc
Olomouc, Czech Republic, Czechia
Actively Recruiting
4
General University Hospital
Prague, Czech Republic, Czechia
Actively Recruiting
5
Tomáš Baťa Regional Hospital in Zlín
Zlín, Czechia
Actively Recruiting
Research Team
D
Daniela Dokoupilová, MSc
L
Lucie Mandelová, Ph.D.
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
PREVENTION
Number of Arms
1
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