Actively Recruiting
Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries
Led by Center for International Blood and Marrow Transplant Research · Updated on 2023-05-03
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Participants Needed
1
Research Sites
N/A
Total Duration
On this page
AI-Summary
What this Trial Is About
Researchers are establishing a Research Sample Repository to collect blood samples related to histocompatibility and hematopoietic cell transplantation (HCT) or other cellular therapies. This repository supports research aimed at understanding molecular factors affecting transplant outcomes, studying tissue type distributions, and evaluating the success of transplantation and supportive care in marrow toxic injuries. The research includes anonymous studies and aims to facilitate broader scientific investigations in these areas. The repository accepts samples from four main groups: donors of hematopoietic cells or other cellular therapies, cord blood units used in treatment, recipients of hematopoietic cell transplants or cellular therapies, and patients treated for marrow toxic injuries. Samples come from donors who have donated or plan to donate cells, cord blood units infused at treatment centers, transplant or therapy recipients, and marrow toxic injury patients receiving various treatments including supportive care or stem cell transplants. Participants contribute samples that are made available to researchers for various analyses including genomic and biomolecular studies. The primary goal is to provide blood samples for research related to histocompatibility and transplantation outcomes. Participation includes adults and children with or without decision-making capacity. The repository facilitates access to these samples for approved research, supporting studies from multiple centers and investigators over an extended period.
CONDITIONS
Brief Title
Protocol for a Research Sample Repository for Hematopoietic Cell Transplantation, Other Cellular Therapies and Marrow Toxic Injuries
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Donors who have donated or are scheduled to donate hematopoietic cells or cellular therapy products to an allogeneic recipient
- All donors registered on the National Marrow Donor Program Registry
- Testable material from cord blood units infused at participating treatment centers
- All U.S. recipients of allogeneic or autologous hematopoietic cell transplants or cellular therapies
- Patients treated for marrow toxic injury at centers participating in the Radiation Injury Treatment Network
- Participants include adults and children with or without decision-making capacity
You will not qualify if you...
History of severe allergic reactions to study medication Currently pregnant or breastfeeding Recent participation in another clinical trial within the last 30 days Presence of uncontrolled medical conditions that could affect safety
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Your Study Journey
Duration - 2 to 4 weeks
Participants are screened for eligibility to participate in the trial.
1 visit (in-person)
Duration - Ongoing during the study period
Participants provide research samples related to hematopoietic cell transplantation, cellular therapies, or marrow toxic injuries.
Visits occur as samples are collected from donors, recipients, or patients depending on treatment schedules
Duration - Up to study completion in July 2030
Participants are followed over time to observe outcomes related to hematopoietic cell transplantation and cellular therapies through collected samples.
Periodic visits depending on cohort assignment and sample availability
Trial Site Locations
Total: 1 location
1
NMDP Biorepository
New Brighton, Minnesota, United States, 55112
Actively Recruiting
Research Team
A
Ashley Spahn
How is the study designed?
Study Type
OBSERVATIONAL
Masking
N/A
Allocation
N/A
Model
N/A
Primary Purpose
N/A
Number of Arms
0
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