Actively Recruiting
Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients
Led by Region Skane · Updated on 2026-04-01
1850
Participants Needed
22
Research Sites
239 weeks
Total Duration
On this page
AI-Summary
What this Trial Is About
The objective of this trial is to assess the beneficial and harmful effects of a restrictive strategy for administration of non-resuscitation fluids in adult patients with septic shock.
CONDITIONS
Official Title
Protocolized Reduction of Non-resuscitation Fluids Versus Usual Care in Septic Shock Patients
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Adult (18 years of age or older)
- Septic shock diagnosed within 12 hours after ICU admission according to Sepsis 3 criteria (suspected or confirmed infection, plasma lactate above 2 mmol/L, and need for vasopressors to maintain mean arterial pressure of 65 mmHg or above after adequate fluid resuscitation >1L within 12 hours)
- Need for vasopressors at the time of screening
You will not qualify if you...
- Confirmed or suspected pregnancy
- Previous participation in the trial
- Screening performed more than 12 hours after ICU admission
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 22 locations
1
Helsinki University Hospital
Helsinki, Finland
Actively Recruiting
2
Kuopio University Hospital
Kuopio, Finland
Not Yet Recruiting
3
Tampere University Hospital
Tampere, Finland
Not Yet Recruiting
4
Turku University Hospital
Turku, Finland
Not Yet Recruiting
5
Danderyd Hospital
Danderyd, Sweden
Actively Recruiting
6
Malar Hospital
Eskilstuna, Sweden
Actively Recruiting
7
Falun Hospital
Falun, Sweden
Actively Recruiting
8
Sahlgrenska University Hospital
Gothenburg, Sweden
Actively Recruiting
9
Östra Hospital
Gothenburg, Sweden
Actively Recruiting
10
Halmstad Hospital
Halmstad, Sweden
Actively Recruiting
11
Helsingborg Hospital
Helsingborg, Sweden
Actively Recruiting
12
Skåne University Hospital, Lund
Lund, Sweden
Actively Recruiting
13
Skåne University Hospital, Malmö
Malmö, Sweden
Actively Recruiting
14
Norrtälje Hospital
Norrtälje, Sweden
Actively Recruiting
15
Örebro University Hospital
Örebro, Sweden
Actively Recruiting
16
Östersund Hospital
Östersund, Sweden
Actively Recruiting
17
Södertälje Hospital
Södertälje, Sweden
Not Yet Recruiting
18
Stockholm South General Hospital (SÖS)
Stockholm, Sweden
Actively Recruiting
19
University Hospital of Umeå
Umeå, Sweden
Actively Recruiting
20
Uppsala University Hospital
Uppsala, Sweden
Actively Recruiting
21
Varberg Hospital
Varberg, Sweden
Actively Recruiting
22
University Hospital of Wales
Cardiff, United Kingdom
Not Yet Recruiting
Research Team
P
Peter Bentzer
CONTACT
J
Jane Fisher
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
TRIPLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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