Actively Recruiting
Proton SBRT for Spinal Metastasis
Led by Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins · Updated on 2026-04-29
12
Participants Needed
1
Research Sites
262 weeks
Total Duration
On this page
Sponsors
S
Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Lead Sponsor
S
Sibley Foundation
Collaborating Sponsor
AI-Summary
What this Trial Is About
This is a single-arm pilot study of proton stereotactic body radiotherapy (SBRT) for nonhematologic spinal metastasis in patients with complex lesions that are unable to be effectively treated with standard of care photon SBRT defined as inability to develop a photon SBRT plan that achieves adequate coverage (≥80% planning treatment volume (PTV) coverage)) with a prescription dose of 30 Gy in 5 fractions.
CONDITIONS
Official Title
Proton SBRT for Spinal Metastasis
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Histologic or cytologic proof of nonhematologic cancer from primary or metastatic site
- Radiographic evidence of spinal metastasis on MRI
- Complex cases not treatable effectively with photon SBRT achieving less than 80% tumor coverage at 30 Gy in 5 fractions, including extensive paraspinal disease, epidural extension (Bilsky grade 61c), or reirradiation
- Age 18 years or older
- ECOG performance status 0 to 2 (Karnofsky >60%)
- Patients of childbearing potential must use adequate contraception
- Ability and willingness to sign informed consent
- Awareness of the investigational nature of the study and provision of written informed consent
You will not qualify if you...
- Cases suitable for standard photon SBRT achieving at least 80% tumor coverage at 30 Gy in 5 fractions
- Inability to receive MRI scans
- Uncontrolled illnesses such as active infection, symptomatic heart failure, unstable angina, cardiac arrhythmias, or psychiatric/social conditions limiting study compliance
AI-Screening
AI-Powered Screening
Complete this quick 3-step screening to check your eligibility
Trial Site Locations
Total: 1 location
1
Johns Hopkins Hospital
Baltimore, Maryland, United States, 21287
Actively Recruiting
Research Team
K
Kristin Redmond, MD
CONTACT
R
Ryan Manuel
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
NA
Model
SINGLE_GROUP
Primary Purpose
TREATMENT
Number of Arms
1
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