Proton Therapy Research Infrastructure ProTRAIT for Neuro-oncology Patients

What this Trial Is About

Researchers are studying the use of proton therapy for treating certain brain tumors with a favorable prognosis. Proton therapy has the potential to reduce radiation exposure to healthy tissues compared to traditional photon therapy, which may lower the risk of radiation-induced complications and secondary tumors. This research follows a model-based approach to select patients who might benefit from proton therapy by comparing individual treatment plans and predicting clinical benefit using Normal Tissue Complication Probability models. The study is observational and collects standardized data from Dutch patients receiving proton or photon therapy. Participants receive follow-up care at outpatient clinics with evaluations by physicians, physician assistants, or trial nurses. Follow-up visits are scheduled at 2.5, 5, 7.5, and 10 years after radiotherapy. The study infrastructure supports collecting clinical data, 3D imaging, and dosimetry information to continuously update and validate prediction models related to proton therapy in neuro-oncology. During the study, researchers monitor neurocognitive function and record outcomes such as neurocognitive failure and memory recall declines at five years post-radiotherapy. Participants undergo regular assessments and data collection during scheduled visits. The study aims to improve the understanding of proton therapy's effects on brain tumors, with long-term follow-up extending up to 10 years after treatment.

Proton Therapy Research Infrastructure- ProTRAIT- Neuro-oncology