Actively Recruiting
Provider-Mediated Communication of Genetic Testing Results to At-Risk Relatives of Cancer Patients to Improve Genetic Counseling and Testing Rates, Family HOPE Study
Led by City of Hope Medical Center · Updated on 2026-01-05
240
Participants Needed
1
Research Sites
200 weeks
Total Duration
On this page
Sponsors
C
City of Hope Medical Center
Lead Sponsor
N
National Cancer Institute (NCI)
Collaborating Sponsor
AI-Summary
What this Trial Is About
This clinical trial tests whether provider-mediated communication of genetic testing results to at-risk relatives of cancer patients can help improve genetic counseling and testing rates. Approximately 15% of people with cancer have an inherited form of cancer due to changes in a gene that they have inherited from one of their parents. These changes increase a person's risk for developing cancer. Most people who have an inherited harmful change in a cancer risk gene don't know that they have it and are therefore not able to get the health care that they need. The primary reason for this problem has been a lack of genetic counseling and testing for cancer patients and patients with a strong family history of cancer. Another reason for this lack of awareness is that, when cancer runs in a family, the patient who carries the gene change usually has to communicate the genetic risk information to their family members. When this process doesn't work well, family members may not know that they need to get genetic testing and then may not get potentially life-saving care. Provider-mediated contact to discuss genetic test results may help improve rates of genetic testing among at-risk relatives of patients with a family cancer syndrome.
CONDITIONS
Official Title
Provider-Mediated Communication of Genetic Testing Results to At-Risk Relatives of Cancer Patients to Improve Genetic Counseling and Testing Rates, Family HOPE Study
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Patient enrolled in City of Hope institutional review board 07047 or seen by City of Hope Genetics for genetic testing
- Patient has a pathogenic or likely pathogenic germline variant
- Patient is fluent in English
- Patient is 18 years or older
- Patient willing to provide contact information for eligible first-degree relatives
- Patient has at least 2 first-degree relatives eligible for genetic testing who live in the United States
- First-degree relatives are related to a proband who is a City of Hope patient and has consented to the study
- First-degree relatives reside in the United States
- First-degree relatives have not had genetic testing for the known familial variant
- First-degree relatives are fluent in English
- First-degree relatives are 18 years or older
You will not qualify if you...
- Patients unable to provide informed consent
- Patients with fewer than 2 at-risk first-degree relatives eligible for genetic testing or living in the United States
- Patients unwilling to provide contact information for family members
- First-degree relatives unable or unwilling to provide informed consent
- First-degree relatives have already had genetic testing for the known familial variant
- First-degree relatives live outside of the United States
AI-Screening
AI-Powered Screening
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Trial Site Locations
Total: 1 location
1
City of Hope Medical Center
Duarte, California, United States, 91010
Actively Recruiting
How is the study designed?
Study Type
INTERVENTIONAL
Masking
NONE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
HEALTH_SERVICES_RESEARCH
Number of Arms
2
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