Actively Recruiting
Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Trial
Led by Michelle Ghert, MD · Updated on 2025-11-10
334
Participants Needed
6
Research Sites
278 weeks
Total Duration
On this page
Sponsors
M
Michelle Ghert, MD
Lead Sponsor
C
Canadian Cancer Society (CCS)
Collaborating Sponsor
AI-Summary
What this Trial Is About
The goal of this clinical trial is to find out if removing and replacing part of the hip bone works better than using metal hardware to stabilize the bone in patients whose cancer has spread to the hip. The main questions are: 1. Does removing and replacing part of the bone work better than just stabilizing it with metal hardware? 2. Does removing and replacing the bone help reduce problems like cancer coming back or the metal hardware breaking? Researchers will compare two treatments: using metal rods and plates to stabilize the bone (internal fixation) versus removing part of the bone and possibly replacing the hip joint (resection and reconstruction) to see if the second option causes fewer problems. Participants will: * Be randomly assigned to one of two groups (internal fixation or resection and reconstruction). * Have one of the two surgeries based on which group they're in. * Go to follow-up appointments with the study doctor at 2 weeks, 6 weeks, 4 months, 6 months, 9 months, and 12 months after surgery.
CONDITIONS
Official Title
Proximal FEmur Reconstruction or Internal Fixation fOR Metastases (PERFORM) Trial
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Life expectancy of at least 6 months
- Lesions located in the proximal femur including femoral neck, intertrochanteric region, subtrochanteric region, or combinations
- Low or intermediate risk for surgery-related complications or death
- Bone loss between 25% and 75%
- Patient and doctor have mutually decided to perform surgery for an impending or actual fracture from metastatic bone disease in the proximal femur
You will not qualify if you...
- Lesions limited to the femoral neck only
- Lesions involving any part of the femoral head
- High risk for surgery-related complications or death
- Medical team decided that removal of the entire lesion is necessary
AI-Screening
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Trial Site Locations
Total: 6 locations
1
Parkview Packnett Family Cancer Institute
Fort Wayne, Indiana, United States, 46845
Actively Recruiting
2
Good Samaritan Regional Medical Center
Corvallis, Oregon, United States, 97330
Actively Recruiting
3
Oregon Health and Science University Hospital
Portland, Oregon, United States, 97239
Not Yet Recruiting
4
Cliniques Universitaires Saint-Luc
Brussels, Belgium, 1200
Not Yet Recruiting
5
Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil, 90450050
Actively Recruiting
6
AOU Città della Salute e della Scienza CTO hospital
Torino, To, Italy, 10126
Not Yet Recruiting
Research Team
O
Olivia Virag, MA
CONTACT
H
Hadia Farrukh
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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