Actively Recruiting
Proximal Versus Total Gastrectomy for Locally Advanced Siewert Type II-III Gastroesophageal Junction Cancer
Led by Nurettin Şahin · Updated on 2026-03-20
120
Participants Needed
1
Research Sites
365 weeks
Total Duration
On this page
Sponsors
N
Nurettin Şahin
Lead Sponsor
A
Ankara City Hospital Bilkent
Collaborating Sponsor
AI-Summary
What this Trial Is About
This multicenter prospective randomized clinical trial aims to compare the safety and oncological effectiveness of proximal gastrectomy and total gastrectomy in patients with locally advanced Siewert type II-III gastroesophageal junction cancer. Eligible patients will be randomly assigned to undergo either proximal gastrectomy or total gastrectomy using open, laparoscopic, or robotic surgical approaches according to clinical suitability. The primary outcome of the study is 3-year disease-free survival. Secondary outcomes include postoperative mortality, postoperative complications, and the number of metastatic lymph nodes retrieved. Patients will be followed for up to five years after surgery to evaluate long-term oncological outcomes.
CONDITIONS
Official Title
Proximal Versus Total Gastrectomy for Locally Advanced Siewert Type II-III Gastroesophageal Junction Cancer
Who Can Participate
Eligibility Criteria
You may qualify if you...
- Age between 18 and 90 years
- Histologically confirmed locally advanced Siewert type II-III gastroesophageal junction cancer
- Considered operable after multidisciplinary tumor board evaluation
- Candidate for curative surgical resection with D2 lymphadenectomy
- Provision of written informed consent
You will not qualify if you...
- Early-stage gastroesophageal junction cancer
- Gastric cancers located in the antrum or corpus
- Severe anesthetic risk (American Society of Anesthesiologists [ASA] class IV or higher)
- Pregnancy
- Patients unwilling or unable to provide informed consent
AI-Screening
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Trial Site Locations
Total: 1 location
1
Bakirkoy Dr. Sadi Konuk Training and Research Hospital
Istanbul, Istanbul, Turkey (Türkiye), 34147
Actively Recruiting
Research Team
T
Turgut Donmez, MD
CONTACT
T
Tolga Dinc, MD
CONTACT
How is the study designed?
Study Type
INTERVENTIONAL
Masking
SINGLE
Allocation
RANDOMIZED
Model
PARALLEL
Primary Purpose
TREATMENT
Number of Arms
2
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