Comparing Single Injections of Low-Dose and High-Dose Platelet-Rich Plasma Versus Saline for Treating Glenohumeral Osteoarthritis

What this Trial Is About

Researchers are evaluating the effects of platelet-rich plasma PRP injections in patients with glenohumeral osteoarthritis, a common joint condition causing pain and stiffness in the shoulder. This study compares single injections of low-dose PRP, high-dose PRP, and saline placebo to better understand their impact on shoulder function and pain. Previous studies focused only on low-dose PRP and lacked a comparison to saline, so this trial aims to fill that gap with a randomized controlled design. Participants will be randomly assigned to receive one injection of either low-dose PRP 3 times the platelet concentration of whole blood, high-dose PRP 12 times the platelet concentration, or saline directly into the glenohumeral joint. The injections are given once, and the study uses triple masking to maintain objectivity. This phase 4 trial monitors outcomes up to 12 months after the injection. During the study, participants will be assessed using the American Shoulder and Elbow Surgeons ASES Shoulder Score at 3 months and other measures like pain rating scales, global health questionnaires, upper extremity function tests, medication use, sleep disturbance, and patient satisfaction up to 12 months after injection. Researchers will track these outcomes to evaluate the treatment effects and safety under medical supervision. Participation involves regular follow-ups and assessments over the year-long observation period.

PRP for Glenohumeral Osteoarthritis